PHARMACOKINETICS OF BENZATHINE PENICILLIN-G - SERUM LEVELS DURING THE 28 DAYS AFTER INTRAMUSCULAR INJECTION OF 1,200,000 UNITS

Simple item page
dc.contributor.authorKAPLAN, EL
dc.contributor.authorBERRIOS, X
dc.contributor.authorSPETH, J
dc.contributor.authorSIEFFERMAN, T
dc.contributor.authorGUZMAN, B
dc.contributor.authorQUESNY, F
dc.date.accessioned2025-01-23T19:23:49Z
dc.date.available2025-01-23T19:23:49Z
dc.date.issued1989
dc.description.abstractBecause of published data suggesting the inadequacy of once-every-4-weeks intramuscular injections of benzathine penicillin G for secondary rheumatic fever prevention, serum penicillin levels were determined at 1, 3, 10, 21 and 28 days after administration of 1,200,000 units of this repository penicillin. A total of 193 samples were studied. Mean serum penicillin levels remained .gtoreq. 0.02 .mu.g/ml for 21 days, but by 28 days only 44% of the serum samples had detectable levels of penicillin and only 36% had levels .gtoreq. 0.02 .mu.g/ml. Patients weighing more than 45 kg had significantly lower serum penicillin levels than did those who weighed less. There were similar correlations with body surface area and with age. These data indicate that a significant percentage of patients receiving benzathine penicillin G prophylaxis for prevention of recurrent attacks of rheumatic fever are not protected during the fourth week. More frequent administration of benzathine penicillin G should be considered in instances of high risk of recurrence of rheumatic fever.
dc.fuente.origenWOS
dc.identifier.eissn1097-6833
dc.identifier.issn0022-3476
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99269
dc.identifier.wosidWOS:A1989AE79800030
dc.issue.numero1
dc.language.isoen
dc.pagina.final150
dc.pagina.inicio146
dc.revistaJournal of pediatrics
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePHARMACOKINETICS OF BENZATHINE PENICILLIN-G - SERUM LEVELS DURING THE 28 DAYS AFTER INTRAMUSCULAR INJECTION OF 1,200,000 UNITS
dc.typeartículo
dc.volumen115
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas