Precise excision of the large pathogenicity island, SP17, in Salmonella enterica serovar Typhi

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dc.article.number90297
dc.contributor.authorBueno, S.M.
dc.contributor.authorSantiviago, C.A.
dc.contributor.authorMurillo, A.A.
dc.contributor.authorFuentes, J.A.
dc.contributor.authorTrombert, A.N.
dc.contributor.authorRodas, P.I.
dc.contributor.authorYouderian, P.
dc.contributor.authorMora, G.C.
dc.date.accessioned2025-04-15T10:30:30Z
dc.date.available2025-04-15T10:30:30Z
dc.date.issued2004
dc.description.abstractThe large pathogenicity island (SPI7) of Salmonella enterica serovar Typhi is a 133,477-bp segment of DNA flanked by two 52-bp direct repeats overlapping the pheU (phenylalanyl-tRNA) gene, contains 151 potential open reading frames, and includes the viaB operon involved in the synthesis of Vi antigen. Some clinical isolates of S. enterica serovar Typhi are missing the entire SPI7, due to its precise excision; these strains have lost the ability to produce Vi antigen, are resistant to phage Vi-II, and invade a human epithelial cell line more rapidly. Excision of SPI7 occurs spontaneously in a clinical isolate of S. enterica serovar Typhi when it is grown in the laboratory, leaves an intact copy of the pheU gene at its novel join point, and results in the same three phenotypic consequences. SPI7 is an unstable genetic element, probably an intermediate in the pathway of lateral transfer of such pathogenicity islands among enteric gram-negative bacteria.
dc.description.funderFIC NIH HHS
dc.description.funderNIGMS NIH HHS
dc.description.funderFOGARTY INTERNATIONAL CENTER
dc.description.funderNATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
dc.fechaingreso.objetodigital2025-09-22
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1128/JB.186.10.3202-3213.2004
dc.identifier.eissn1098-5530
dc.identifier.issn0021-9193
dc.identifier.pubmedidMEDLINE:15126483
dc.identifier.scopusidScopus_ID:85197748046
dc.identifier.urihttps://doi.org/10.1128/JB.186.10.3202-3213.2004
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103281
dc.identifier.wosidWOS:000221310400034
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramirez, Susan Marcela; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Gonzalez Munoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.issue.numero10
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final3213
dc.pagina.inicio3202
dc.revistaJOURNAL OF BACTERIOLOGY
dc.rightsacceso abierto
dc.subjectCOMPLETE GENOME SEQUENCE
dc.subjectVI ANTIGEN
dc.subjectNUCLEOTIDE-SEQUENCE
dc.subjectPROPHAGE INSERTION
dc.subjectSECRETED PROTEIN
dc.subjectPLASMID R64
dc.subjectIVB PILI
dc.subjectSTRAINS
dc.subjectTYPHIMURIUM
dc.subjectENCODES
dc.subject.ddc800
dc.subject.deweyLiteraturaes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePrecise excision of the large pathogenicity island, SP17, in Salmonella enterica serovar Typhi
dc.typeartículo
dc.volumen186
sipa.codpersvinculados113541
sipa.codpersvinculados15616
sipa.codpersvinculados90610
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-04-2025
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