Maternal obesity is associated with a higher number of regulatory-T-cells in newborns without affecting suppression

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dc.contributor.authorArroyo-Jousse, Viviana
dc.contributor.authorBorzutzky, Arturo
dc.contributor.authorRosa Bono, Maria
dc.contributor.authorCasanello, Paola
dc.date.accessioned2025-01-20T20:16:50Z
dc.date.available2025-01-20T20:16:50Z
dc.date.issued2023
dc.description.abstractBackgroundMaternal obesity (MO) is associated with a higher risk of immune-mediated diseases in the offspring and higher leptin levels in cord blood (CB). This study evaluates the number and function of lymphocyte subtypes in CB related to MO and its relationship with leptin concentration and leptin receptor expression. MethodsPregnant women with (n = 32) or without obesity (n = 41) were enrolled at delivery. Cord blood mononuclear cells were separated with Ficoll-Hypaque. B and CD4+, regulatory and effector T cells were quantified by Flow Cytometry. Cord blood leptin concentration was measured by ELISA, and the leptin receptor (sLepR) on Treg cells was determined by Flow Cytometry. ResultsMO was associated with higher numbers of CD4+, Treg and effector T cells in the CB of their offspring, without differences in the suppressive function of Tregs. Female offspring had a higher number of these cells and a higher cord leptin concentration. Tregs expressed higher levels of sLepR than effector T cells, without differences between groups. ConclusionsMO is associated with changes in the newborn's immune profile, more evident in female newborns with higher leptin concentrations. More studies are needed to identify the mechanisms by which the high levels of cord leptin in the newborn of women with obesity could affect the offspring's immune system.
dc.fuente.origenWOS
dc.identifier.doi10.1111/aji.13687
dc.identifier.eissn1600-0897
dc.identifier.issn1046-7408
dc.identifier.urihttps://doi.org/10.1111/aji.13687
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92357
dc.identifier.wosidWOS:000944388600001
dc.issue.numero4
dc.language.isoen
dc.revistaAmerican journal of reproductive immunology
dc.rightsacceso restringido
dc.subjectleptin
dc.subjectleptin receptor
dc.subjectmaternal obesity
dc.subjectregulatory T cells
dc.subjectsex dimorphism
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMaternal obesity is associated with a higher number of regulatory-T-cells in newborns without affecting suppression
dc.typeartículo
dc.volumen89
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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