Repeated Treatment With the κ-Opioid Agonist U-69593 Increases K<SUP>+</SUP>-Stimulated Dopamine Release in the Rat Medial Prefrontal Cortex

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dc.contributor.authorAntonio Fuentealba, Jose
dc.contributor.authorGysling, Katia
dc.contributor.authorEstela Andres, Maria
dc.date.accessioned2025-01-21T00:04:14Z
dc.date.available2025-01-21T00:04:14Z
dc.date.issued2010
dc.description.abstractAcute activation of K-opioid receptors (KOR) decreases dopamine (DA) extracellular levels in both the medial prefrontal cortex (mPFC) and the nucleus accumbens (NAc). Also, the acute activation of KOR prevents alterations in behavior and neurochemistry occurring after repeated use of psychostimulants. Opposing to the acute effects, repeated administration of the KOR agonist, U-6593, potentiates both high-potassium and amphetamine induced DA release in the NAc, suggesting that repeated activation of KOR sensitizes mesolimbic dopaminergic neurotransmission. This study investigated the effect of repeated treatment with U-69593 on basal and stimulated DA and serotonin (5HT) extracellular levels in the rat mPFC. Rats were injected once daily with U-69593 (0.16-0.32 mg/kg) or vehicle for 4 days. One day after the last injection, microdialysis experiments assessing DA and 5HT extracellular levels in mPFC were conduced. The repeated treatment with U-69593 significantly augmented potassium-stimulated DA extracellular levels, without affecting potassium-stimulated 5HT extracellular levels, suggesting an increase in DA releasability. Synapse 64:898 904, 2010. (C)2010 Wiley-Liss, Inc.
dc.fuente.origenWOS
dc.identifier.doi10.1002/syn.20808
dc.identifier.eissn1098-2396
dc.identifier.issn0887-4476
dc.identifier.urihttps://doi.org/10.1002/syn.20808
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95498
dc.identifier.wosidWOS:000283611600003
dc.issue.numero12
dc.language.isoen
dc.pagina.final904
dc.pagina.inicio898
dc.revistaSynapse
dc.rightsacceso restringido
dc.subjectkappa-opioid receptor
dc.subjectmicrodialysis
dc.subjectamphetamine
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRepeated Treatment With the κ-Opioid Agonist U-69593 Increases K<SUP>+</SUP>-Stimulated Dopamine Release in the Rat Medial Prefrontal Cortex
dc.typeartículo
dc.volumen64
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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