Risk Factors and Mechanisms Leading to Preschool Recurrent Wheeze and Asthma

Simple item page
dc.catalogadorjlo
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorWolters, Alba A. B.
dc.contributor.authorRodriguez-Martinez, Carlos E.
dc.contributor.authorBiagini, Jocelyn M.
dc.contributor.authorCeledón, Juan C.
dc.contributor.authorCustovic, Adnan
dc.contributor.authorKoppelman, Gerard H.
dc.contributor.authorPhipatanakal, Wanda
dc.contributor.authorSaglani, Sejal
dc.contributor.authorForno, Erick
dc.date.accessioned2025-08-28T18:45:23Z
dc.date.available2025-08-28T18:45:23Z
dc.date.issued2025
dc.description.abstractPreschool recurrent wheezing is a prevalent and heterogeneous condition that can develop into childhood asthma, significantly damaging public health. Preschool recurrent wheeze and asthma are influenced by a multifactorial interplay of biological, environmental, early life, behavioral, and psychosocial factors. Genes such as Gasdermin B, Orosomucoid 1-like 3, Cadherin-related family member 3, Annexin A1, and IL33/IL1RL1, and the methylation of cell–type–specific CpG sites are associated with airway-remodeling, increased inflammatory responses, and enhanced susceptibility to environmental factors. Biomarkers such as allergen sensitization, blood eosinophil levels, FeNO, and volatile organic compounds may guide treatment decisions based on the type of immune response in wheezing episodes. Several asthma-predicted clinical indices have been developed, and some have been validated. Although lower airway samples obtained through bronchoalveolar lavage and biopsy in young children are limited, they are essential in understanding the pathophysiology and developing personalized treatment of recurrent preschool wheezing. Early evaluations of lung function, airway hyperresponsiveness, and bronchodilator response can be valuable objective tools. However, because of physiologic variability and inconsistent methods and definitions, these tests cannot confirm or rule out a diagnosis of asthma at preschool age. Future research should investigate the interplay of factors across biological, environmental, and social domains to enhance predictive models and inform targeted interventions that promote health equity and reduce the global burden of preschool recurrent wheeze and asthma.
dc.format.extent14 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.jaip.2025.07.051
dc.identifier.issn2213-2198
dc.identifier.urihttps://doi.org/10.1016/j.jaip.2025.07.051
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105330
dc.information.autorucEscuela de Medicina; Castro Rodríguez, José Antonio; 0000-0002-0708-4281; 113247
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaThe Journal of Allergy and Clinical Immunology: In Practice
dc.rightsacceso restringido
dc.subjectPreschool
dc.subjectRecurrent wheezing
dc.subjectAsthma
dc.subjectRisk factors
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRisk Factors and Mechanisms Leading to Preschool Recurrent Wheeze and Asthma
dc.typeartículo
sipa.codpersvinculados113247
sipa.trazabilidadORCID;2025-08-22
Files
Collections
Artículos de revistas