Dyspnoea and respiratory muscle ultrasound to predict extubation failure

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dc.contributor.authorDres, Martin
dc.contributor.authorSimilowski, Thomas
dc.contributor.authorGoligher, Ewan C.
dc.contributor.authorPham, Tai
dc.contributor.authorSergenyuk, Liliya
dc.contributor.authorTelias, Irene
dc.contributor.authorGrieco, Domenico Luca
dc.contributor.authorOuechani, Wissale
dc.contributor.authorJunhasavasdikul, Detajin
dc.contributor.authorSklar, Michael C.
dc.contributor.authorDamiani, L. Felipe
dc.contributor.authorMelo, Luana
dc.contributor.authorSantis, Cesar
dc.contributor.authorDegravi, Lauriane
dc.contributor.authorDecavele, Maxens
dc.contributor.authorBrochard, Laurent
dc.contributor.authorDemoule, Alexandre
dc.date.accessioned2025-01-20T22:04:12Z
dc.date.available2025-01-20T22:04:12Z
dc.date.issued2021
dc.description.abstractBackground This study investigated dyspnoea intensity and respiratory muscle ultrasound early after extubation to predict extubation failure.
dc.description.abstractMethods The study was conducted prospectively in two intensive care units in France and Canada. Patients intubated for at least 48 h were studied within 2 h after an extubation following a successful spontaneous breathing trial. Dyspnoea was evaluated by a dyspnoea visual analogue scale (Dyspnoea-VAS) ranging from 0 to 10 and the Intensive Care Respiratory Distress Observational Scale (IC-RDOS). The ultrasound thickening fraction of the parasternal intercostal and the diaphragm was measured; limb muscle strength was evaluated using the Medical Research Council (MRC) score (range 0-60).
dc.description.abstractResults Extubation failure occurred in 21 out of 122 enrolled patients (17%). The median (interquartile range (IQR)) Dyspnoea-VAS and IC-RDOS were higher in patients with extubation failure versus success: 7 (4-9) versus 3 (1-5) (p<0.001) and 3.7 (1.8-5.8) versus 1.7 (1.5-2.1) (p<0.001), respectively. The median (IQR) ratio of parasternal intercostal muscle to diaphragm thickening fraction was significantly higher and MRC was lower in patients with extubation failure compared with extubation success: 0.9 (0.4-2.1) versus 0.3 (0.2-0.5) (p<0.001) and 45 (36-50) versus 52 (44-60) (p=0.012), respectively. The thickening fraction of the parasternal intercostal and its ratio to diaphragm thickening showed the highest area under the receiver operating characteristic curve (AUC) for an early prediction of extubation failure (0.81). AUCs of Dyspnoea-VAS and IC-RDOS reached 0.78 and 0.74, respectively.
dc.description.abstractConclusions Respiratory muscle ultrasound and dyspnoea measured within 2 h after extubation predict subsequent extubation failure.
dc.fuente.origenWOS
dc.identifier.doi10.1183/13993003.00002-2021
dc.identifier.eissn1399-3003
dc.identifier.issn0903-1936
dc.identifier.urihttps://doi.org/10.1183/13993003.00002-2021
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94070
dc.identifier.wosidWOS:000728820200013
dc.issue.numero5
dc.language.isoen
dc.revistaEuropean respiratory journal
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDyspnoea and respiratory muscle ultrasound to predict extubation failure
dc.typeartículo
dc.volumen58
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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