HEPATIC PRODUCTION OF VERY-LOW-DENSITY LIPOPROTEIN, CATABOLISM OF LOW-DENSITY-LIPOPROTEIN, BILIARY LIPID SECRETION, AND BILE-SALT SYNTHESIS IN RATS FED A BEAN (PHASEOLUS-VULGARIS) DIET

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dc.contributor.authorMARZOLO, MP
dc.contributor.authorAMIGO, L
dc.contributor.authorNERVI, F
dc.date.accessioned2025-01-23T19:21:48Z
dc.date.available2025-01-23T19:21:48Z
dc.date.issued1993
dc.description.abstractRats fed a bean diet develop a significant hypocholesterolemia. The catabolism of low density lipoprotein (LDL; d 1.019-1.063 g/ml) was studied in vivo and in vitro in the isolated perfused liver of rats fed either a casein or a bean diet. The clearance of LDL was significantly increased by 100% from 0.38 +/- 0.04 to 0.63 +/- 0.04 ml/h x 100 g body wt in vivo in the bean-fed rat. Similarly, the clearance of homologous and heterologous (human) LDL was also increased by 100% in the isolated perfused liver of bean-fed animals. Spleen, kidney, and hepatic cholesterogenesis was increased by 150% in these animals. Bile salt synthesis was increased from 1.54 +/- 0.02 to 2.84 +/- 0.09 nmol/min x g liver wt (P < 0.02) and biliary cholesterol output by 200% from 0.81 +/- 0.03 to 2.18 +/- 0.04 nmol/min x g (P < 0.02) in the isolated perfused liver of rats fed a bean diet. These results explained the depletion of hepatic cholesterol and were consistent with the LDL turnover studies, suggesting that apoB/E receptor activity was increased in these animals. ApoB and triglyceride secretion in the d < 1.060 g/ml lipoprotein fraction of liver perfusates remained normal in the bean-fed rats. In contrast, total sinusoidal cholesterol output isolated in the d < 1.060 g/ml fraction significantly decreased by 100% after 90 min of perfusion. Cholesterol output in the d > 1.060 g/ml lipoprotein fraction was unmodified by the bean diet. These data demonstrate that key metabolic pathways of hepatic cholesterol are modified in the bean-fed rat. These modifications are consistent with hypocholesterolemia induced by this legume. The marked excretion of hepatic cholesterol into the bile associated with a decreased output of sinusoidal cholesterol in apoB-containing lipoproteins suggest a functional reciprocal interrelationship between both cholesterol secretory pathways in the bean-fed animals.
dc.fuente.origenWOS
dc.identifier.issn0022-2275
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98875
dc.identifier.wosidWOS:A1993LD27900011
dc.issue.numero5
dc.language.isoen
dc.pagina.final814
dc.pagina.inicio807
dc.revistaJournal of lipid research
dc.rightsacceso restringido
dc.subjectLIPOPROTEIN PRODUCTION AND CATABOLISM
dc.subjectBILIARY CHOLESTEROL
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHEPATIC PRODUCTION OF VERY-LOW-DENSITY LIPOPROTEIN, CATABOLISM OF LOW-DENSITY-LIPOPROTEIN, BILIARY LIPID SECRETION, AND BILE-SALT SYNTHESIS IN RATS FED A BEAN (PHASEOLUS-VULGARIS) DIET
dc.typeartículo
dc.volumen34
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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