Adaptive evolution of the insulin gene in caviomorph rodents

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dc.catalogadoraba
dc.contributor.authorOpazo, J. C.
dc.contributor.authorPalma Vásquez, Ramón Eduardo
dc.contributor.authorMelo Ledermann, Francisco Javier
dc.contributor.authorLessa, E. P.
dc.date.accessioned2025-02-06T19:32:44Z
dc.date.available2025-02-06T19:32:44Z
dc.date.issued2005
dc.description.abstractInsulin is a conservative molecule among mammals, maintaining both its structure and function. Rodents that belong to the Suborder Hystricognathi represent an exception, having a very divergent molecule with unusual physiological properties. In this work, we analyzed the evolutionary pattern of the insulin gene in caviomorph rodents (South American hystricomorph rodents). We found that these rodents have higher rates of nonsynonymous:synonymous substitutions (dN/dS) than nonhystricomorph rodents and that values are heterogeneous inside the group. We estimated codons under positive selection, specifically the second binding site (A13 and B17) and others related with hexamerization (B18, B20, and B22). In the monomer structure, all selected sites formed a single patch around the second binding site. In the hexamer structure, these amino acids were grouped into three major patches. In this structure, contacts between B chains involved all selected sites (except B18), and between faces in the center of the molecule, all contacts were among selected sites. While there is no clear hypothesis regarding the cause of this drastic change, experimental evidence does show that this group of rodents has some peculiarities in growth function, and, whether coincidental or not, these changes appeared together with important changes in life-history traits.
dc.fechaingreso.objetodigital2025-05-26
dc.format.extent9 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.1093/molbev/msi117
dc.identifier.eissn1537-1719
dc.identifier.issn0737-4038
dc.identifier.scopusid2-s2.0-17744376584
dc.identifier.urihttps://doi.org/10.1093/molbev/msi117
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102185
dc.identifier.wosidWOS:000228700200015
dc.information.autorucFacultad de Ciencias Biológicas; Palma Vásquez, Ramón Eduardo; 0000-0002-0806-1268; 100250
dc.information.autorucFacultad de Ciencias Biológicas; Melo Ledermann, Francisco Javier; 0000-0002-0424-5991; 82342
dc.issue.numeroNo. 5
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final1298
dc.pagina.inicio1290
dc.revistaMolecular biology and evolution
dc.rightsacceso abierto
dc.subjectInsulin
dc.subjectCaviomorph
dc.subjectAdaptive evolution
dc.subjectLife-history traits
dc.subjectHystricognathi
dc.subject.ddc570
dc.subject.deweyBiología
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAdaptive evolution of the insulin gene in caviomorph rodents
dc.typeartículo
dc.volumenVol. 22
sipa.codpersvinculados100250
sipa.codpersvinculados82342
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