Free-breathing, non-contrast, 3D whole-heart coronary MRI for the identification of culprit and vulnerable atherosclerotic plaque

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dc.catalogadoraba
dc.contributor.authorHajhosseiny, Reza
dc.contributor.authorHartley, Adam
dc.contributor.authorCole, Graham
dc.contributor.authorMunoz, Camilla
dc.contributor.authorSethi, Amarjit
dc.contributor.authorAl-Lamee, Rasha
dc.contributor.authorKhawaja, Saud
dc.contributor.authorZaman, Sameer
dc.contributor.authorHoward, James
dc.contributor.authorGopalan, Deepa
dc.contributor.authorAriff, Ben
dc.contributor.authorKaprielian, Raffi
dc.contributor.authorNeji, Radhouene
dc.contributor.authorKunze, Karl P.
dc.contributor.authorKaura, Amit
dc.contributor.authorPrieto Vásquez, Claudia
dc.contributor.authorKhamis, Ramzi
dc.contributor.authorBotnar, René Michael
dc.date.accessioned2025-05-16T19:07:07Z
dc.date.available2025-05-16T19:07:07Z
dc.date.issued2025
dc.description.abstractBACKGROUND: Detection of vulnerable coronary plaque can predict future myocardial infarctions. We have developed a novel, non-contrast cardiovascular magnetic resonance sequence (iT2prep-BOOST), enabling simultaneous, co-registered coronary angiography and plaque detection.OBJECTIVES: To validate iT2prep-BOOST in patients with non-ST-segment elevation myocardial infarction (NSTEMI).METHODS: 41 patients with suspected NSTEMI were recruited. Invasive coronary angiography ± intravascular imaging was used to classify coronary segments into the following categories: normal, non-culprit and culprit segments; stenosed segments as well as segments with vulnerable plaque features (lipid, calcium, fibroatheroma, thin cap fibroatheroma (TCFA), plaque-rupture and thrombus). The plaque/myocardial signal intensity ratio (PMR) in each coronary segment was analyzed on iT2prep-BOOST.RESULTS: The mean ± standard deviation PMR of culprit segments was significantly higher than non-culprit segments and normal segments (1.01 ± 0.14 vs. 0.67 ± 0.18 vs. 0.35 ± 0.24, P<0.001 respectively). Coronary segments with lipid, calcium and fibroatheroma had a significantly higher PMR compared to normal coronary segments (P<0.001), but significantly lower than segments with plaque-rupture and intraluminal thrombus (P<0.05). There was a progressive increase in PMR with increasing coronary segment stenosis (P<0.001). There was a significant association on multivariable analysis between HbA1c as well as family history of coronary artery disease and mean PMR (P=0.05 and P=0.04 respectively).CONCLUSIONS: iT2prep-BOOST has the potential to simultaneously visualize coronary artery lumen and plaque and differentiate normal segments from non-culprit and culprit plaque segments non-invasively and without contrast. The prognostic value of PMR needs to be investigated in a prospective multicenter study.
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.jocmr.2025.101898
dc.identifier.eissn1532-429X
dc.identifier.issn1097-6647
dc.identifier.urihttps://kclpure.kcl.ac.uk/portal/en/publications/7806cc68-ec54-4a05-b064-da47fb049487
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104351
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia; 0000-0003-4602-2523; 14195
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Botnar, René Michael; 0000-0003-2811-2509; 1015313
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaJournal of Cardiovascular Magnetic Resonance
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCoronary artery disease
dc.subjectAtherosclerosis
dc.subjectVulnerable plaque
dc.subjectCMR
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFree-breathing, non-contrast, 3D whole-heart coronary MRI for the identification of culprit and vulnerable atherosclerotic plaque
dc.typeartículo
dc.volumen27
sipa.codpersvinculados14195
sipa.codpersvinculados1015313
sipa.trazabilidadORCID;2025-05-07
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