Neurotrophin Signaling Impairment by Viral Infections in the Central Nervous System

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dc.article.number5817
dc.contributor.authorBohmwald Prieto, Karen
dc.contributor.authorAndrade Parra, Catalina Andrea
dc.contributor.authorMora Rivera, Valentina Paz
dc.contributor.authorMuñoz Flores, José Tomas
dc.contributor.authorRamírez Inostroza, Robinson Alonso
dc.contributor.authorRojas Hernández, María Fernanda
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.date.accessioned2024-01-31T14:30:25Z
dc.date.available2024-01-31T14:30:25Z
dc.date.issued2022
dc.description.abstractNeurotrophins, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3), NT-4, and NT-5, are proteins involved in several important functions of the central nervous system. The activation of the signaling pathways of these neurotrophins, or even by their immature form, pro-neurotrophins, starts with their recognition by cellular receptors, such as tropomyosin receptor kinase (Trk) and 75 kD NT receptors (p75NTR). The Trk receptor is considered to have a high affinity for attachment to specific neurotrophins, while the p75NTR receptor has less affinity for attachment with neurotrophins. The correct functioning of these signaling pathways contributes to proper brain development, neuronal survival, and synaptic plasticity. Unbalanced levels of neurotrophins and pro-neurotrophins have been associated with neurological disorders, illustrating the importance of these molecules in the central nervous system. Furthermore, reports have indicated that viruses can alter the normal levels of neurotrophins by interfering with their signaling pathways. This work discusses the importance of neurotrophins in the central nervous system, their signaling pathways, and how viruses can affect them.
dc.description.funderAgencia Nacional de Investigacion y Desarrollo (ANID): -ANID/FONDECYT/INICIACION
dc.description.funderAgencia Nacional de Investigacion y Desarrollo (ANID): -ANID/FONDAP
dc.description.funderAgencia Nacional de Investigacion y Desarrollo (ANID): -ANID/Millennium Science Initiative
dc.fechaingreso.objetodigital2024-05-30
dc.format.extent19 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms23105817
dc.identifier.eisbn978-3-030-28856-3
dc.identifier.eissn1422-0067
dc.identifier.isbn978-3-030-28855-6
dc.identifier.issn0733-4648
dc.identifier.pubmedidMEDLINE:35050804
dc.identifier.scopusidSCOPUS_ID:85171188545
dc.identifier.urihttps://doi.org/10.3390/ijms23105817
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81152
dc.identifier.wosidWOS:000802481600001
dc.information.autorucFacultad de Ciencias Biológicas; Andrade Parra Catalina Andrea; 0000-0003-2623-1387; 234276
dc.information.autorucFacultad de Ciencias Biológicas; Mora Rivera, Valentina Paz; 0000-0002-7948-9907; 1066802
dc.information.autorucFacultad de Ciencias Biológicas; Muñoz Flores, José Tomas; S/I ; 1066803
dc.information.autorucFacultad de Ciencias Biológicas; Ramírez Inostroza, Robinson Alonso; 0009-0007-0788-3802; 1089001
dc.information.autorucFacultad de Ciencias Biológicas; Rojas Hernández, María Fernanda; S/I; 1135351
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.issue.numero10
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final19
dc.pagina.inicio1
dc.publisherSPRINGER INTERNATIONAL PUBLISHING AG
dc.relation.ispartofPediatric Obesity
dc.revistaInternational Journal of Molecular Science
dc.rightsacceso abierto
dc.subjectNeurotrophins
dc.subjectNeurotrophins signaling
dc.subjectViral infection
dc.subjectNeurological alterations
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNeurotrophin Signaling Impairment by Viral Infections in the Central Nervous System
dc.typeartículo
dc.volumen23
sipa.codpersvinculados234276
sipa.codpersvinculados1066802
sipa.codpersvinculados1066803
sipa.codpersvinculados1089001
sipa.codpersvinculados1135351
sipa.codpersvinculados90610
sipa.indexWOS
sipa.trazabilidadCarga SIPA;31-01-2024
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