Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels

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dc.article.number9579
dc.catalogadorjca
dc.contributor.authorCarvajal-Oliveros, Angel
dc.contributor.authorDomínguez-Baleón, Carmen
dc.contributor.authorZárate, Rafaella V.
dc.contributor.authorCampusano, Jorge M.
dc.contributor.authorNarváez-Padilla, Verónica
dc.contributor.authorReynaud, Enrique
dc.date.accessioned2024-02-27T16:02:48Z
dc.date.available2024-02-27T16:02:48Z
dc.date.issued2021
dc.description.abstractIt has been observed that there is a lower Parkinson’s disease (PD) incidence in tobacco users. Nicotine is a cholinergic agonist and is the principal psychoactive compound in tobacco linked to cigarette addiction. Different studies have shown that nicotine has beneficial effects on sporadic and genetic models of PD. In this work we evaluate nicotine’s protective effect in a Drosophila melanogaster model for PD where Synphilin-1 (Sph-1) is expressed in dopaminergic neurons. Nicotine has a moderate effect on dopaminergic neuron survival that becomes more evident as flies age. Nicotine is beneficial on fly survival and motility increasing tyrosine hydroxylase and dopamine levels, suggesting that cholinergic agonists may promote survival and metabolic function of the dopaminergic neurons that express Sph-1. The Sph-1 expressing fly is a good model for the study of early-onset phenotypes such as olfaction loss one of the main non-motor symptom related to PD. Our data suggest that nicotine is an interesting therapeutic molecule whose properties should be explored in future research on the phenotypic modulators of the disease and for the development of new treatments.
dc.fechaingreso.objetodigital2024-05-31
dc.fuente.origenORCID
dc.identifier.doi10.1038/s41598-021-88910-4
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-021-88910-4
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-85105400237&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81345
dc.identifier.wosidWOS:000656453000024
dc.information.autorucFacultad de Ciencias Biológicas; Campusano Astorga, Jorge Mauricio; 0000-0001-5254-8340; 3965
dc.information.autorucFacultad de Ciencias Biológicas;Zárate Canales, Rafaella;0000-0001-7250-9007;1031192
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final13
dc.pagina.inicio1
dc.revistaScientific Reports
dc.rightsacceso abierto
dc.subjectBiochemistry
dc.subjectCell death in the nervous system
dc.subjectDiseases of the nervous system
dc.subjectGenetics of the nervous system
dc.subjectNeurochemistry
dc.subjectNeuroscience
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels
dc.typeartículo
dc.volumen11
sipa.codpersvinculados3965
sipa.codpersvinculados1031192
sipa.trazabilidadORCID;2024-01-15
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