Economic benefits of treating medication-overuse headache - results from the multicenter COMOESTAS project

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dc.contributor.authorJellestad, Pernille Linde
dc.contributor.authorCarlsen, Louise Ninett
dc.contributor.authorWestergaard, Maria Lurenda
dc.contributor.authorMunksgaard, Signe Bruun
dc.contributor.authorBendtsen, Lars
dc.contributor.authorLainez, Miguel
dc.contributor.authorFadic, Ricardo
dc.contributor.authorKatsarava, Zaza
dc.contributor.authorTeresa Goicochea, Maria
dc.contributor.authorSpadafora, Santiago
dc.contributor.authorJensen, Rigmor Hojland
dc.contributor.authorNappi, Giuseppe
dc.contributor.authorTassorelli, Cristina
dc.contributor.authorSances, Grazia
dc.contributor.authorAllena, Marta
dc.contributor.authorRapsch, Marina
dc.contributor.authorLopez, Beatriz
dc.contributor.authorShand, Beatriz
dc.date.accessioned2025-01-23T21:17:07Z
dc.date.available2025-01-23T21:17:07Z
dc.date.issued2019
dc.description.abstractBackground Medication-overuse headache is a costly disease for individuals and society.
dc.description.abstractObjective To estimate the impact of medication-overuse headache treatment on direct and indirect headache-related health care costs.
dc.description.abstractMethods This prospective longitudinal study was part of the COMOESTAS project (COntinuous MOnitoring of Medication Overuse Headache in Europe and Latin America: development and STAndardization of an Alert and decision support System). Patients with medication-overuse headache were included from four European and two Latin American headache centers. Costs of acute medication, costs of health care services, and measurements of productivity were calculated at baseline and at 6-month follow-up Treatment consisted of overused drug withdrawal with optional preventive medication.
dc.description.abstractResults A total of 475 patients (71%) completed treatment and were followed up for 6 months. Direct health care costs were on average reduced significantly by 52% (p<0.001) for the total study population. Significant reductions were seen in both number of consumed tablets (-71%, p<0.001) and number of visits to physicians (-43%, p<0.001). Fifty percent of patients reduced their number of consumed tablets80%. Headache-related productivity loss, calculated either as absence from work or50% reduction of productivity during the workday, were reduced by 21% and 34%, respectively (p<0.001).
dc.description.abstractConclusion Standardized treatment of medication-overuse headache in six countries significantly reduced direct health care costs and increased productivity. This emphasizes the importance of increasing awareness of the value of treating medication-overuse headache.
dc.description.abstractTrial registration The trial was registered at ClinicalTrials.gov (no. NCT02435056)
dc.description.funderCOMOESTAS Project - EC
dc.fuente.origenWOS
dc.identifier.doi10.1177/0333102418786265
dc.identifier.eissn1468-2982
dc.identifier.issn0333-1024
dc.identifier.urihttps://doi.org/10.1177/0333102418786265
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101147
dc.identifier.wosidWOS:000459778200012
dc.issue.numero2
dc.language.isoen
dc.pagina.final285
dc.pagina.inicio274
dc.revistaCephalalgia
dc.rightsacceso restringido
dc.subjectMedication-overuse
dc.subjectdetoxification
dc.subjectdirect health care costs
dc.subjectproductivity loss
dc.subjectmedication consumption
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEconomic benefits of treating medication-overuse headache - results from the multicenter COMOESTAS project
dc.typeartículo
dc.volumen39
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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