Malnutrition early in life impairs alpha-2 adrenoreceptor regulation of noradrenaline release in the rat cerebral cortex

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dc.contributor.authorBelmar, J
dc.contributor.authorCarreno, P
dc.contributor.authorHernandez, A
dc.contributor.authorSotoMoyano, R
dc.date.accessioned2025-01-21T01:33:46Z
dc.date.available2025-01-21T01:33:46Z
dc.date.issued1996
dc.description.abstractExperimental studies have shown that malnutrition early in life results in enhanced release of noradrenaline (NA) in the brain. The disturbed mechanism underlying this neurochemical disorder is pearly understood. To test the possibility that early malnutrition could disrupt the feedback mechanism regulating the release of NA at central axon terminals, the ability of the adrenoreceptor agonist clonidine to depress NA overflow was studied in rat cortex slices arising from malnourished rats. Protein-energy malnutrition was induced by increasing litter size from 8 to 18 pups per nurse. Results show that clonidine (5 x 10(-6) M) induced a significant decrease of the spontaneous release of NA in occipital cortex slices obtained from 23-24 day-old normal rats and of the potassium-evoked release of NA in slices arised from normal animals of 45-50 days of age. On the contrary, clonidine induced a significant increase of both the spontaneous and evoked outflow of the neurotransmitter in slices arised from malnourished rats of the two ages. Results indicate that protein-energy malnutrition impairs the alpha-2 receptor mechanisms regulating central NA overflow, probably by altering during development the quantity and/or quality of the adrenoreceptor population.
dc.fuente.origenWOS
dc.identifier.issn0271-5317
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97468
dc.identifier.wosidWOS:A1996VK31300011
dc.issue.numero10
dc.language.isoen
dc.pagina.final1734
dc.pagina.inicio1727
dc.revistaNutrition research
dc.rightsacceso restringido
dc.subjectmalnutrition
dc.subjectnoradrenaline
dc.subjectadrenoreceptors
dc.subjectclonidine
dc.subjectcerebral Cortex
dc.subjectrat
dc.subject.ods02 Zero Hunger
dc.subject.odspa02 Hambre cero
dc.titleMalnutrition early in life impairs alpha-2 adrenoreceptor regulation of noradrenaline release in the rat cerebral cortex
dc.typeartículo
dc.volumen16
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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