Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in <i>Xenopus</i> embryos

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dc.contributor.authorMuñoz, R
dc.contributor.authorMoreno, M
dc.contributor.authorOliva, C
dc.contributor.authorOrbenes, C
dc.contributor.authorLarraín, J
dc.date.accessioned2025-01-21T01:06:11Z
dc.date.available2025-01-21T01:06:11Z
dc.date.issued2006
dc.description.abstractEarly shaping of Xenopus laevis embryos occurs through convergent and extension movements, a process that is driven by intercalation of polarized dorsal mesodermal cells and regulated by non-canonical Wnt signalling(1-3). Here, we have identified Xenopus syndecan-4 (xSyn4), a cell-surface transmembrane heparan sulphate proteoglycan. At the gastrula stage, xSyn4 is expressed in the involuting dorsal mesoderm and the anterior neuroectoderm. Later, it is found in the pronephros, branchial arches, brain and tailbud. Both gain- and loss-of-function of xSyn4 impaired convergent extension movements in Xenopus embryos and in activin-treated ectodermal explants. xSyn4 interacts functionally and biochemically with the Wnt receptor Frizzled7 (xFz7) and its signal transducer Dishevelled (xDsh). Furthermore, xSyn4 is necessary and sufficient for translocation of xDsh to the plasma membrane - a landmark in the activation of non-canonical Wnt signalling(1-3). Our results suggest that the ability of xSyn4 to translocate xDsh is regulated by fibronectin, a component of the extracellular matrix required for proper convergent extension movements(4-6). We propose a model where xSyn4 and fibronectin cooperate with xFz7 and Wnt in the specific activation of the non-canonical Wnt pathway.
dc.fuente.origenWOS
dc.identifier.doi10.1038/ncb1399
dc.identifier.eissn1476-4679
dc.identifier.issn1465-7392
dc.identifier.urihttps://doi.org/10.1038/ncb1399
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96106
dc.identifier.wosidWOS:000237299400013
dc.issue.numero5
dc.language.isoen
dc.pagina.finalU123
dc.pagina.inicio492
dc.revistaNature cell biology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSyndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in <i>Xenopus</i> embryos
dc.typeartículo
dc.volumen8
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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