High altitude pulmonary edema in children: A systematic review

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dc.catalogadorjlo
dc.contributor.authorUcrós, Santiago
dc.contributor.authorAparicio, Camila
dc.contributor.authorCastro Rodriguez, José Antonio
dc.contributor.authorIvy, Dunbar
dc.date.accessioned2024-01-29T17:48:30Z
dc.date.available2024-01-29T17:48:30Z
dc.date.issued2022
dc.description.abstractAbstract Introduction: High altitude pulmonary edema (HAPE) is a form of acutenoncardiogenic pulmonary edema caused by altitude‐related hypoxia seen inchildren as well as in adults. In this systematic review we focus in HAPE occurringin children and adolescents.Methods:A systematic review was conducted including publications in children0–18 years of age from three databases up to June 2022.Results:Thirty‐five studies representing 210 cases were found. The mean age was9.8 ± 3.6 years with a male/female ratio of 2.6. The peak age incidence was seen inchildren between 6 and 10 years old. Only two children (0.9%) were≤2 years old.The mean altitude in 166 cases was 2861 masl. Only 17 cases (8.1%) occurred ataltitudes below 2500 masl. Regarding the different HAPE subtypes there was apredominance of re‐entry HAPE (R‐HAPE) with 58%, followed by classic HAPE(C‐HAPE) with 37.6%. The mean time between arrival and onset of symptoms was16.5 h. The mortality rate was 1.4%. In 10/28 (36%) of C‐HAPE cases there was astructural cardiac/pulmonary anomaly compared to 1/19 (5%) in R‐HAPE (p< 0.01).HAPE recurrence was found in 46 cases (21.9%). The involvement in the chest X‐rays was seen predominantly in the apices and in the right lung.Conclusions:R‐HAPE was the most common HAPE subtype; HAPE peak age wasfound between 6 and 10 years of age; HAPE was more frequent in males and wasrare in children under 2 years old; associated HAPE structural abnormalities weremore common in C‐HAPE than in R‐HAPE.
dc.fechaingreso.objetodigital2024-11-14
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1002/ppul.26294
dc.identifier.issn8755-6863
dc.identifier.urihttps://doi.org/10.1002/ppul.26294
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81025
dc.identifier.wosidWOS:000905084900001
dc.information.autorucEscuela de Medicina; Castro Rodríguez, José Antonio; 0000-0002-0708-4281; 113247
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1067
dc.pagina.inicio1059
dc.revistaPediatric Pulmonology
dc.rightsacceso restringido
dc.subjectAltitude
dc.subjectChildren
dc.subjectHigh altitude
dc.subjectPulmonary hypertension
dc.subjectMountain sickness
dc.subjectPulmonary edema
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHigh altitude pulmonary edema in children: A systematic review
dc.typeartículo
dc.volumen58
sipa.codpersvinculados113247
sipa.trazabilidadORCID;2024-01-15
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