EFFECT OF AGING ON BILIARY LIPID-COMPOSITION AND BILE-ACID METABOLISM IN NORMAL CHILEAN WOMEN

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dc.contributor.authorVALDIVIESO, V
dc.contributor.authorPALMA, R
dc.contributor.authorWUNKHAUS, R
dc.contributor.authorANTEZANA, C
dc.contributor.authorSEVERIN, C
dc.contributor.authorCONTRERAS, A
dc.date.accessioned2025-01-23T19:44:52Z
dc.date.available2025-01-23T19:44:52Z
dc.date.issued1978
dc.description.abstractBiliary lipid composition was determined in fasting gallbladder bile of 12 young and 12 elderly asymptomatic Chilean women with normal weights and recent, normal cholecystograms. The proportion of biliary cholesterol and the lithogenic index were significantly higher in elderly females. Moreover, supersaturated bile was present in 8.3% of the young and in 41.7% of the older women studied. Obesity enhances the saturation of bile in older females: lithogenic bile was found in 100% of 4 elderly, obese women with radiologically normal gallbladders. The bile acid pool and cholic acid metabolism were studied in 5 young and 4 older normal females. Both groups showed similar values of bile acid pool, cholic acid synthesis and turnover. Aging per se modifies the proportions of biliary lipids in Chilean women, and provide a partial explanation for the frequency of gallstones observed among them. The increment in the lithogenic index of gallbladder bile with age takes place without significant changes in bile acid metabolism, suggesting that the canalicular secretion of cholesterol increases with aging.
dc.fuente.origenWOS
dc.identifier.eissn1528-0012
dc.identifier.issn0016-5085
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100146
dc.identifier.wosidWOS:A1978EZ13800014
dc.issue.numero5
dc.language.isoen
dc.pagina.final874
dc.pagina.inicio871
dc.revistaGastroenterology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECT OF AGING ON BILIARY LIPID-COMPOSITION AND BILE-ACID METABOLISM IN NORMAL CHILEAN WOMEN
dc.typeartículo
dc.volumen74
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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