PLATELET 5-HYDROXYTRYPTAMINE INCREASES WITH PLATELET AGE IN DOGS

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dc.contributor.authorMEZZANO, D
dc.contributor.authorDELPINO, GE
dc.contributor.authorMONTESINOS, M
dc.contributor.authorGARCIA, ME
dc.contributor.authorARANDA, E
dc.contributor.authorFORADORI, A
dc.date.accessioned2024-01-10T13:16:18Z
dc.date.available2024-01-10T13:16:18Z
dc.date.issued1991
dc.description.abstractThrombocytopenia was induced in mongrel dogs by two mechanisms: immunologically, by intravenous injection of heterologous antiplatelet antibody, and non-immunologically, by circulating the blood through glass beads in anesthetized animals. The platelet content of 5-HT was monitored before and during the recovery of the blood platelet counts. This period is associated with the normalization of the mean platelet survival time and with a progressive increase in the mean age of the circulating platelet population. A continuous increment in platelet 5-HT closely followed the increase in platelet counts in both models of thrombocytopenia, and a strong correlation was found between the platelet age and 5-HT content. These findings support the concept that platelets accumulate 5-HT during their physiological aging process, contradicting the notion that a negative balance in 5-HT content results at the end of their physiological lifespan in circulation. These results are not in conflict with the concept that circulating platelets release and re-uptake 5-HT.
dc.fechaingreso.objetodigital2024-06-14
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1055/s-0038-1646399
dc.identifier.eissn2567-689X
dc.identifier.issn0340-6245
dc.identifier.pubmedidMEDLINE:1771619
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78574
dc.identifier.wosidWOS:A1991FZ97100012
dc.information.autorucMatemática;Del Pino G;S/I;99446
dc.information.autorucMedicina;Mezzano D;S/I;99455
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final258
dc.pagina.inicio254
dc.publisherGEORG THIEME VERLAG KG
dc.revistaTHROMBOSIS AND HAEMOSTASIS
dc.rightsacceso restringido
dc.subjectTHROMBIN-TREATED PLATELETS
dc.subjectDENSITY SUBPOPULATIONS
dc.subjectSEROTONIN
dc.subjectSTORAGE
dc.subjectDISEASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePLATELET 5-HYDROXYTRYPTAMINE INCREASES WITH PLATELET AGE IN DOGS
dc.typeartículo
dc.volumen66
sipa.codpersvinculados99446
sipa.codpersvinculados99455
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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