Astroglial Hemichannels and Pannexons: The Hidden Link between Maternal Inflammation and Neurological Disorders

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dc.article.number9503
dc.catalogadorgjm
dc.contributor.authorPrieto Villalobos, Juan Carlos
dc.contributor.authorAlvear Soto, Tanhia Francheska
dc.contributor.authorLiberona, Andres
dc.contributor.authorLucero, Claudia M.
dc.contributor.authorMartinez Araya, Claudio J.
dc.contributor.authorBalmazabal, Javiera
dc.contributor.authorInostroza, Carla A.
dc.contributor.authorRamírez Rojas, Gigliola
dc.contributor.authorGomez, Gonzalo I.
dc.contributor.authorOrellana Roca, Juan Andrés
dc.date.accessioned2024-10-16T14:54:43Z
dc.date.available2024-10-16T14:54:43Z
dc.date.issued2021
dc.description.abstractMaternal inflammation during pregnancy causes later-in-life alterations of the offspring's brain structure and function. These abnormalities increase the risk of developing several psychiatric and neurological disorders, including schizophrenia, intellectual disability, bipolar disorder, autism spectrum disorder, microcephaly, and cerebral palsy. Here, we discuss how astrocytes might contribute to postnatal brain dysfunction following maternal inflammation, focusing on the signaling mediated by two families of plasma membrane channels: hemi-channels and pannexons. [Ca2+](i) imbalance linked to the opening of astrocytic hemichannels and pannexons could disturb essential functions that sustain astrocytic survival and astrocyte-to-neuron support, including energy and redox homeostasis, uptake of K+ and glutamate, and the delivery of neurotrophic factors and energy-rich metabolites. Both phenomena could make neurons more susceptible to the harmful effect of prenatal inflammation and the experience of a second immune challenge during adulthood. On the other hand, maternal inflammation could cause excitotoxicity by producing the release of high amounts of gliotransmitters via astrocytic hemichannels/pannexons, eliciting further neuronal damage. Understanding how hemichannels and pannexons participate in maternal inflammation-induced brain abnormalities could be critical for developing pharmacological therapies against neurological disorders observed in the offspring.
dc.description.funderAgencia Nacional de Investigacion y Desarrollo (ANID)
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
dc.fechaingreso.objetodigital2024-10-16
dc.format.extent23 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/ijms22179503
dc.identifier.eissn1422-0067
dc.identifier.pubmedidMEDLINE:34502412
dc.identifier.urihttps://doi.org/10.3390/ijms22179503
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88257
dc.identifier.wosidWOS:000694414100001
dc.information.autorucEscuela de Medicina; Prieto Villalobos, Juan Carlos; S/I; 1071673
dc.information.autorucEscuela de Medicina; Alvear Soto, Tanhia Francheska; S/I; 1246198
dc.information.autorucS/I; Ramírez Rojas, Gigliola; S/I; 1001936
dc.information.autorucEscuela de Medicina; Orellana Roca, Juan Andrés; 0000-0003-4076-207X; 126007
dc.issue.numero17
dc.language.isoen
dc.nota.accesocontenido completo
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectConnexins
dc.subjectPannexins
dc.subjectHemichannels
dc.subjectPannexons
dc.subjectNeuroinflammation
dc.subjectLipopolysaccharide
dc.subjectNeuron
dc.subjectAstrocyte
dc.subjectMicroglia
dc.subjectNeurodegeneration
dc.subjectExcitotoxicity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAstroglial Hemichannels and Pannexons: The Hidden Link between Maternal Inflammation and Neurological Disorders
dc.typeartículo
dc.volumen22
sipa.codpersvinculados1071673
sipa.codpersvinculados1246198
sipa.codpersvinculados1001936
sipa.codpersvinculados126007
sipa.trazabilidadORCID;2024-10-14
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