Implementation of the updated Sydney system biopsy protocol improves the diagnostic yield of gastric preneoplastic conditions: Results from a real-world study

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dc.contributor.authorLatorre, Gonzalo
dc.contributor.authorVargas, Jose Ignacio
dc.contributor.authorShah, Shailja C.
dc.contributor.authorIvanovic-Zuvic, Danisa
dc.contributor.authorAchurra, Pablo
dc.contributor.authorFritzsche, Martin
dc.contributor.authorLeung, Jai-Sen
dc.contributor.authorRamos, Bernardita
dc.contributor.authorJensen, Elisa
dc.contributor.authorUribe, Javier
dc.contributor.authorMontero, Isabella
dc.contributor.authorGandara, Vicente
dc.contributor.authorRobles, Camila
dc.contributor.authorBustamante, Miguel
dc.contributor.authorSilva, Felipe
dc.contributor.authorDukes, Eitan
dc.contributor.authorCorsi, Oscar
dc.contributor.authorMartinez, Francisca
dc.contributor.authorBinder, Victoria
dc.contributor.authorCandia, Roberto
dc.contributor.authorEspino, Alberto
dc.contributor.authorAgueero, Carlos
dc.contributor.authorSharp, Allan
dc.contributor.authorTorres, Javiera
dc.contributor.authorRoa, Juan Carlos
dc.contributor.authorPizarro, Margarita
dc.contributor.authorCorvalan, Alejandro H.
dc.contributor.authorRabkin, Charles S.
dc.contributor.authorCamargo, M. Constanza
dc.contributor.authorRiquelme, Arnoldo
dc.date.accessioned2025-01-20T16:07:09Z
dc.date.available2025-01-20T16:07:09Z
dc.date.issued2024
dc.description.abstractBackground: The updated Sydney system biopsy protocol (USSBP) standardizes the sampling of gastric biopsies for the detection of preneoplastic conditions ( e.g. , gastric intestinal metaplasia [GIM]), but the real-world diagnostic yield is not well-described. Aim: To determine whether regular application of USSBP is associated with higher detection of chronic atrophic gastritis (CAG), GIM and autoimmune gastritis (AIG). Methods: We performed a real-world retrospective study at an academic urban tertiary hospital in Chile. We manually reviewed medical records from consecutive patients undergoing esophagogastroduodenoscopy (EGD) from January to December 2017. Seven endoscopists who performed EGDs were categorized into two groups (USSBP 'regular' and USSBP 'infrequent') based on USSBP adherence, using minimum 20% adherence as the prespecified threshold. Multivariable logistic regression models were used to estimate the odds ratios (aOR) and 95% confidence intervals (CI) for the association between endoscopist groups and the likelihood of diagnosing CAG, GIM or AIG. Results: 1206 patients were included in the study (mean age: 58.5; 65.3% female). The USSBP regular group demonstrated a higher likelihood of detecting CAG (20% vs . 5.3%; aOR 4.03, 95%CI: 2.69-6.03), GIM (12.2% vs. 3.4%; aOR 3.91, 95%CI: 2.39-6.42) and AIG (2.9% vs. 0.8%; aOR 6.52, 95%CI: 1.87-22.74) compared to infrequent group. Detection of advanced-stage CAG (Operative Link for Gastritis Assessment stage III/IV) was significantly higher in the USSBP regular vs. infrequent group (aOR 5.84, 95%CI: 2.23-15.31). Conclusions: Routine adherence to USSBP increases the detection rates of preneoplastic conditions, including CAG, GIM and AIG. Standardized implementation of USSBP should be considered in high gastric cancer risk populations. (c) 2023 Elsevier Espana, S.L.U. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.gastrohep.2023.08.005
dc.identifier.issn0210-5705
dc.identifier.urihttps://doi.org/10.1016/j.gastrohep.2023.08.005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89982
dc.identifier.wosidWOS:001327977400001
dc.issue.numero8
dc.language.isoen
dc.pagina.final803
dc.pagina.inicio793
dc.revistaGastroenterologia y hepatologia
dc.rightsacceso restringido
dc.subjectHelicobacter pylori
dc.subjectGastric cancer
dc.subjectEndoscopy
dc.subjectGastritis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImplementation of the updated Sydney system biopsy protocol improves the diagnostic yield of gastric preneoplastic conditions: Results from a real-world study
dc.typeartículo
dc.volumen47
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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