Simultaneous 3D T<sub>1</sub>,T<sub>2</sub>, and fat-signal-fraction mapping with respiratory-motion correction for comprehensive liver tissue characterization at 0.55 T

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dc.contributor.authorTripp, Donovan P.
dc.contributor.authorKunze, Karl P.
dc.contributor.authorCrabb, Michael G.
dc.contributor.authorPrieto, Claudia
dc.contributor.authorNeji, Radhouene
dc.contributor.authorBotnar, Rene M.
dc.date.accessioned2025-01-20T16:12:03Z
dc.date.available2025-01-20T16:12:03Z
dc.date.issued2024
dc.description.abstractPurpose: To develop a framework for simultaneous three-dimensional (3D) mapping of T-1, T-2, and fat signal fraction in the liver at 0.55T. Methods: The proposed sequence acquires four interleaved 3D volumes with a two-echo Dixon readout. T-1 and T-2 are encoded into each volume via preparation modules, and dictionary matching allows simultaneous estimation of T-1, T-2, and M0 for water and fat separately. 2D image navigators permit respiratory binning, and motion fields from nonrigid registration between bins are used in a non rigid respiratory-motion-corrected reconstruction, enabling 100% scan efficiency from a free-breathingacquisition.Theintegratednatureoftheframeworkensures the resulting maps are always co-registered. Results: T-1, T-2, and fat-signal-fraction measurements in phantoms correlated strongly (adjusted r(2) > 0.98) with reference measurements. Mean liver tissue parameter values in 10 healthy volunteers were 427 +/- 22, 47.7 +/- 3.3ms, and 7 +/- 2% for T-1, T-2, and fat signal fraction, giving biases of 71,-30.0 ms, and -5 percentage points, respectively, when compared to conventional methods. Conclusion: A novel sequence for comprehensive characterization of liver tissue at 0.55T was developed. The sequence provides co-registered 3D T-1, T-2, and fat-signal-fraction maps with full coverage of the liver, from a single nine-and-a-half-minute free-breathing scan. Further development is needed to achieve accurate proton-density fat fraction (PDFF) estimation in vivo.
dc.fuente.origenWOS
dc.identifier.doi10.1002/mrm.30236
dc.identifier.eissn1522-2594
dc.identifier.issn0740-3194
dc.identifier.urihttps://doi.org/10.1002/mrm.30236
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90310
dc.identifier.wosidWOS:001280201800001
dc.language.isoen
dc.revistaMagnetic resonance in medicine
dc.rightsacceso restringido
dc.subjectliver
dc.subjectlow-field MR
dc.subjectmotion correction
dc.subjectNAFLD
dc.subjectquantitative imaging
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSimultaneous 3D T<sub>1</sub>,T<sub>2</sub>, and fat-signal-fraction mapping with respiratory-motion correction for comprehensive liver tissue characterization at 0.55 T
dc.typeartículo
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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