Effect of in vivo administration of epidermal growth factor on prostaglandin production and NOS activity in term rat placentae.: Possible participation of placental EGF receptors

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dc.contributor.authorRibeiro, ML
dc.contributor.authorFarina, M
dc.contributor.authorBilli, S
dc.contributor.authorMartínez, SP
dc.contributor.authorBrañes, MC
dc.contributor.authorVillalón, M
dc.contributor.authorFranchi, A
dc.date.accessioned2025-01-21T01:06:39Z
dc.date.available2025-01-21T01:06:39Z
dc.date.issued2005
dc.description.abstractMany authors hypothesize that the epidermal growth factor (EGF) is involved in the onset of labor. Previous reports from our laboratory showed that intrauterine administration of EGF delays the beginning of labor. The alms of this study were: 1) to analyze the effect of intrauterine administration of 500 ng EGF on placental prostaglandins and nitric oxide, and 2) to characterize the expression of EGF receptors (EGF-R) in pregnant rat placentae. Saline solution (sham group) and 500 ng EGF (EGF-treated group) were administered via intrauterine injection on day 21 of gestation, and both groups of animals were sacrificed on day 22 (sham rats delivered on day 22). Results showed that EGF treatment: 1) inhibited the production of prostaglandin E (p < 0.001) and F-2 alpha (P < 0.01), 2) increased the synthesis of nitric oxide (p < 0.001), and 3) reduced the expression of cyclooxygenase-II, the enzyme responsible for PG synthesis. Placentae were found to express EGF-R and its activated form, and the expressions of both forms were higher at mid and term pregnancy. Hence, EGF is a very interesting molecule for studying the regulation of placental prostaglandin and nitric oxide production related to the parturition process.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.placenta.2004.10.011
dc.identifier.eissn1532-3102
dc.identifier.issn0143-4004
dc.identifier.urihttps://doi.org/10.1016/j.placenta.2004.10.011
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96198
dc.identifier.wosidWOS:000232812800008
dc.issue.numero10
dc.language.isoen
dc.pagina.final765
dc.pagina.inicio758
dc.revistaPlacenta
dc.rightsacceso restringido
dc.subjectEGF
dc.subjectplacenta
dc.subjectprostaglandins
dc.subjectNOS activity
dc.subjectlabor
dc.subjectEGF receptors
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffect of in vivo administration of epidermal growth factor on prostaglandin production and NOS activity in term rat placentae.: Possible participation of placental EGF receptors
dc.typeartículo
dc.volumen26
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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