Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix

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dc.contributor.authorSaavedra, Kathleen.
dc.contributor.authorBrebi, Priscilla M.
dc.contributor.authorRoa Strauch, Juan Carlos Enrique
dc.date.accessioned2019-10-16T15:17:48Z
dc.date.available2019-10-16T15:17:48Z
dc.date.issued2012
dc.date.updated2019-10-14T18:25:43Z
dc.description.abstractCervical cancer (CC) is one of the most malignant tumors and the second or third most common type of cancer in women worldwide. The association between human papillomavirus (HPV) and CC is widely known and accepted (99.7% of cases). At present, the pathogenesis mechanisms of CC are not entirely clear. It has been shown that inactivation of tumor suppressor genes and activation of oncogenes play a significant role in carcinogenesis, caused by the genetic and epigenetic alterations. In the past, it was generally thought that genetic mutation was a key event of tumor pathogenesis, especially somatic mutation of tumor suppressor genes. With deeper understanding of tumors in recent years, increasing evidence has shown that epigenetic silencing of those genes, as a result of aberrant hypermethylation of CpG islands in promoters and histone modification, is essential to carcinogenesis and metastasis. The term epigenetics refers to heritable changes in gene expression caused by regulation mechanisms, other than changes in DNA sequence. Specific epigenetic processes include DNA methylation, chromotin remodeling, histone modification, and microRNA regulations. These alterations, in combination or individually, make it possible to establish the methylation profiles, histone modification maps, and expression profiles characteristic of this pathology, which become useful tools for screening, early detection, or prognostic markers in cervical cancer. This paper reviews recent epigenetics research progress in the CC study, and tries to depict the relationships between CC and DNA methylation, histone modification, as well as microRNA regulations.
dc.fuente.origenBiomed Central
dc.identifier.citationClinical Epigenetics. 2012 Aug 31;4(1):13
dc.identifier.doi10.1186/1868-7083-4-13
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26541
dc.identifier.wosidWOS:000208830900013
dc.issue.numeroNo. 13
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final7
dc.pagina.inicio1
dc.rightsacceso abierto
dc.rights.holderSaavedra et al.; licensee BioMed Central Ltd.
dc.subjectCervical canceres_ES
dc.subjectHuman papillomaviruses_ES
dc.subjectEpigenetics alterationses_ES
dc.subjectBiomarkerses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.ods05 Gender equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleEpigenetic alterations in preneoplastic and neoplastic lesions of the cervixes_ES
dc.typeartículo
dc.volumenVol. 4
sipa.codpersvinculados84743
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