Subinhibitory antibiotic concentrations promote the excision of a genomic island carried by the globally spread carbapenem- resistant<i> Klebsiella</i><i> pneumoniae</i> sequence type 258

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dc.contributor.authorPina-Iturbe, Alejandro
dc.contributor.authorHoppe-Elsholz, Guillermo
dc.contributor.authorSuazo, Isidora D.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorBueno, Susan M.
dc.date.accessioned2025-01-20T17:21:03Z
dc.date.available2025-01-20T17:21:03Z
dc.date.issued2023
dc.description.abstractThe ICEKp258.2 genomic island (GI) has been proposed as an important factor for the emergence and success of the globally spread carbapenem-resistant Klebsiella pneumoniae sequence type (ST) 258. However, a characterization of this horizontally acquired element is lacking. Using bioinformatic and experimental approaches, we found that ICEKp258.2 is not confined to ST258 and ST512, but also carried by ST3795 strains and emergent invasive multidrug-resistant pathogens from ST1519. We also identified several ICEKp258.2- like GIs spread among different K. pneumoniae STs, other Klebsiella species and even other pathogen genera, uncovering horizontal gene transfer events between different STs and bacterial genera. Also, the compara-tive and phylogenetic analyses of the ICEKp258.2- like GIs revealed that the most closely related ICEKp258.2- like GIs were har-boured by ST11 strains. Importantly, we found that subinhibitory concentrations of antibiotics used in treating K. pneumoniae infections can induce the excision of this GI and modulate its gene expression. Our findings provide the basis for the study of ICEKp258.2 and its role in the success of K. pneumoniae ST258. They also highlight the potential role of antibiotics in the spread of ICEKp258.2- like GIs among bacterial pathogens.
dc.fuente.origenWOS
dc.identifier.doi10.1099/mgen.0.001138
dc.identifier.issn2057-5858
dc.identifier.urihttps://doi.org/10.1099/mgen.0.001138
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91445
dc.identifier.wosidWOS:001126874500005
dc.issue.numero12
dc.language.isoen
dc.revistaMicrobial genomics
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSubinhibitory antibiotic concentrations promote the excision of a genomic island carried by the globally spread carbapenem- resistant<i> Klebsiella</i><i> pneumoniae</i> sequence type 258
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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