Antibacterial Silver Nanoparticles Supported on Graphene Oxide with Reduced Cytotoxicity

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dc.contributor.authorAngulo-Pineda, Carolina
dc.contributor.authorPalma, Patricia
dc.contributor.authorBejarano, Julian
dc.contributor.authorRiveros, Ana
dc.contributor.authorKogan, Marcelo
dc.contributor.authorPalza, Humberto
dc.date.accessioned2025-01-23T21:10:28Z
dc.date.available2025-01-23T21:10:28Z
dc.date.issued2019
dc.description.abstractThe effect of graphene oxide (GO) on both the antibacterial and cytotoxicity behavior of silver nanoparticles (Ag NPs) has been studied. Ag NPs supported on GO were synthesized by two methods, ex situ and in situ. These nanocomposites were characterized by transmission electron microscopy, ultraviolet-visible spectroscopy, Raman spectroscopy, and Fourier-transform infrared spectroscopy. The antibacterial activity of the nanomaterials was evaluated against Escherichia coli and Staphylococcus aureus by the disk-diffusion method and dynamic contact assays. While GO flakes showed antibacterial behavior only in the dynamic contact test, both GO-Ag NPs nanohybrids eradicated bacteria independent of the condition. Noteworthily, the high cytotoxicity of Ag NPs to human-derived cells was dramatically decreased by the GO layers in the nanocomposite. The in situ hybrid particles showed the lowest cytotoxicity without losing the strong antibacterial effect. These results demonstrate that growth of Ag NPs on GO layers could enable the development of a new family of antibacterial materials with low cytotoxicity to human cells.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s11837-019-03633-2
dc.identifier.eissn1543-1851
dc.identifier.issn1047-4838
dc.identifier.urihttps://doi.org/10.1007/s11837-019-03633-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100848
dc.identifier.wosidWOS:000487659800045
dc.issue.numero10
dc.language.isoen
dc.pagina.final3705
dc.pagina.inicio3698
dc.revistaJom
dc.rightsacceso restringido
dc.titleAntibacterial Silver Nanoparticles Supported on Graphene Oxide with Reduced Cytotoxicity
dc.typeartículo
dc.volumen71
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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