CHARACTER OF STORED MOLECULES IN CHROMAFFIN GRANULES OF ADRENAL-MEDULLA - NUCLEAR MAGNETIC-RESONANCE STUDY

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dc.contributor.authorDANIELS, AJ
dc.contributor.authorWILLIAMS, RJP
dc.contributor.authorWRIGHT, PE
dc.date.accessioned2025-01-23T19:44:49Z
dc.date.available2025-01-23T19:44:49Z
dc.date.issued1978
dc.description.abstractThe organization of the internal contents of bovine adrenal chromaffin granules were studied using NMR spectroscopy. The method permits an examination of the interactions between ATP metal ions, adrenaline [epinephrine] and the chromogranin proteins. Particular advantage accrues when the naturally occurring cations Mg and Ca are replaced by Mn cations, since Mn2+ is an effective perturbing probe. Protein spectrum in the vesicles was compared with that of the isolated proteins. There was a loose network of interactions between the various components. The major part of the network was the interaction of the chromogranin protein, shown to have approximately a random coil conformation, with the ATP and the adrenaline. The organized loose structure appeared to lower osmotic pressure without hindering rapid release of the vesicle contents breaking the membrane.
dc.fuente.origenWOS
dc.identifier.eissn1873-7544
dc.identifier.issn0306-4522
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100133
dc.identifier.wosidWOS:A1978FM17600007
dc.issue.numero6
dc.language.isoen
dc.pagina.final585
dc.pagina.inicio573
dc.revistaNeuroscience
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCHARACTER OF STORED MOLECULES IN CHROMAFFIN GRANULES OF ADRENAL-MEDULLA - NUCLEAR MAGNETIC-RESONANCE STUDY
dc.typeartículo
dc.volumen3
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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