Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar

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dc.article.number106217
dc.contributor.authorDomínguez, J.M.
dc.contributor.authorBaudrand, R.
dc.contributor.authorArteaga, E.
dc.contributor.authorCampusano, C.
dc.contributor.authorGonzález, G.
dc.contributor.authorMosso, L.
dc.contributor.authorFardella, C.
dc.contributor.authorArias, T.
dc.contributor.authorPizarro, A.
dc.contributor.authorGómez, M.
dc.contributor.authorCruz, F.
dc.contributor.authorTorres, J.
dc.contributor.authorSolar, A.
dc.contributor.authorCavada, G.
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:29Z
dc.date.available2024-08-15T08:00:29Z
dc.date.issued2009
dc.description.abstractBackground: Thyroid nodules are common and associated to a low risk of malignancy. Their clinical assessment usually includes a fine neddle aspiration biopsy (FNAB). Aim: To identify ultrasonographic characteristics associated to papillary thyroid carcinoma (PTC) and generate a score that predicts the risk of PTC. Material and methods: Retrospective review of all fine needle aspiration biopsies of the thyroid performed in a lapse of two years. Biopsies that were conclusive for PTC were selected and compared with an equal amount of randomly selected biopsies that disclosed a benign diagnosis. Results: One hundred twenty two biopsies of a total of 1,498 were conclusive for PTC. Univariate analysis showed associations with PTC for the presence of micro-calcifications (Odds ratio (OR) 49.2: 95% confidence intervals (CI) 18.7-140.9), solid predominance (OR 25.1; 95% CI 6-220), hypoechogenicity (OR 23.5, 95% CI 6.5-122.6), irregular borders (OR 17, 95% CI 7.2-42.9), lymph node involvement (OR 12.3, 95% CI 2.7-112), central vascularization (OR 12.2, 95% CI 4.8-33.3), local invasion and hyperechogenicity (OR 0.2; CI 95% CI 0.03-0.6). Multivariate analysis disclosed microcalcifications (OR 28.1; CI 95% 8.9-89), hypoechogenicity (OR 9.4; 95% CI 1.5-59.5) and irregular borders (OR 4.7; CI 95% 1.5-15) as the variables independently associated with the presence of PTC. The prevalence of PTC in the presence of the three variables was 97.6% (Likelihood ratio (LR) 45) and 5.4% in their absence (LR 0.06). Conclusions: This scale predicts the presence or absence of PTC using simple ultrasound characteristics.
dc.description.funderANID through FONDECYT
dc.fechaingreso.objetodigital2025-10-15
dc.format.extent6 páginas
dc.fuente.origenScopus
dc.identifier.doi10.4067/S0034-98872009000800005
dc.identifier.eissn07176163
dc.identifier.issn00349887 07176163
dc.identifier.pubmedid19915766
dc.identifier.scopusidSCOPUS_ID:70449129941
dc.identifier.urihttps://doi.org/10.4067/S0034-98872009000800005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87480
dc.identifier.wosidWOS:000228990600008
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero8
dc.language.isoes
dc.nota.accesocontenido completo
dc.pagina.final1036
dc.pagina.inicio1031
dc.revistaRevista Medica de Chile
dc.rightsacceso abierto
dc.subjectBiopsy
dc.subjectCarcinoma
dc.subjectFine-needle
dc.subjectPapillary
dc.subjectThyroid neoplasms
dc.subject.ddc550
dc.subject.deweyCiencias de la tierraes_ES
dc.titleDiseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar
dc.title.alternativeAn ultrasound score to predict the presence of papillary thyroid carcinoma. Preliminary report
dc.typeartículo
dc.volumen137
sipa.codpersvinculados88201
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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