Frailty and reduced gait speed are independently related to mortality of cirrhotic patients in long-term follow-up

Simple item page
dc.contributor.authorSoto, Ruben
dc.contributor.authorAntonio Diaz, Luis
dc.contributor.authorRivas, Violeta
dc.contributor.authorFuentes-Lopez, Eduardo
dc.contributor.authorZalaquett, Macarena
dc.contributor.authorJose Bruera, Maria
dc.contributor.authorGonzalez, Cecilia
dc.contributor.authorMezzano, Gabriel
dc.contributor.authorBenitez, Carlos
dc.date.accessioned2025-01-20T22:04:25Z
dc.date.available2025-01-20T22:04:25Z
dc.date.issued2021
dc.description.abstractIntroduction and objectives: Frailty is characterized by a poor restoration of homeostasis after a stressor event. Although it is not usually diagnosed, it has been associated with decreased survival in cirrhotic patients. We aimed to evaluate the impact of frailty and decreased gait speed over survival in cirrhotic patients at long-term follow-up.
dc.description.abstractMaterials and methods: We included stable cirrhotic patients Child-Pugh B-C or MELD >12, >50 years old. We performed a clinical evaluation, anthropometry, and laboratory tests. Frailty was diagnosed using Fried Frailty Index. We evaluated survival at a 4-year follow-up.
dc.description.abstractResults: We included 126 patients; mean age 64 +/- 8.3 years, median MELD-Na 15[12-17], median follow-up was 881 [349-1277] days. The main etiology was MAFLD (31.4%). Frailty was diagnosed in 65.1% of patients. There were no significant differences in baseline characteristics per frailty condition. Mortality was higher in frail patients than non-frail patients (68.2% versus 20.6% at 48 months, respectively; p-value <0.001). The mean gait speed in frail and non-frail patients was 0.86 +/- 0.3 m/s and 1.16 +/- 0.2 m/s, respec-tively (p-value <0.001). Interestingly, 26.9% of patients presented a reduced gait speed (<= 0.8 m/s). Patients with decreased gait speed also had higher mortality than patients with normal gait speed (79.9% versus 40.8%, respectively; p-value <0.001). A multivariate-adjusted model showed that decreased gait speed (HR = 3.27, 95%CI:1.74-6.14; p < 0.001) and frailty (HR = 4.24, 95%CI:1.89-9.51; p < 0.001) were associated with mortality.
dc.description.abstractConclusions: Frailty is independently associated with decreased survival at long-term follow-up. Reduced gait speed is strongly associated with mortality and could be a surrogate marker of frailty in clinical practice. (C) 2021 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.aohep.2021.100327
dc.identifier.issn1665-2681
dc.identifier.urihttps://doi.org/10.1016/j.aohep.2021.100327
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94086
dc.identifier.wosidWOS:000726788800008
dc.language.isoen
dc.revistaAnnals of hepatology
dc.rightsacceso restringido
dc.subjectFrailty
dc.subjectSarcopenia
dc.subjectCirrhosis
dc.subjectLiver transplantation
dc.subjectMortality
dc.subjectSurvival
dc.subjectMuscle
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.ods02 Zero Hunger
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleFrailty and reduced gait speed are independently related to mortality of cirrhotic patients in long-term follow-up
dc.typeartículo
dc.volumen25
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas