COVID-19 in Adults With Congenital Heart Disease

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dc.contributor.authorBroberg, Craig S.
dc.contributor.authorKovacs, Adrienne H.
dc.contributor.authorSadeghi, Soraya
dc.contributor.authorRosenbaum, Marlon S.
dc.contributor.authorLewis, Matthew J.
dc.contributor.authorCarazo, Matthew R.
dc.contributor.authorRodriguez, Fred H., III
dc.contributor.authorHalpern, Dan G.
dc.contributor.authorFeinberg, Jodi
dc.contributor.authorArancibia Galilea, Francisca
dc.contributor.authorBaraona, Fernando
dc.contributor.authorCedars, Ari M.
dc.contributor.authorKo, Jong M.
dc.contributor.authorPorayette, Prashob
dc.contributor.authorMaldonado, Jennifer
dc.contributor.authorSarubbi, Berardo
dc.contributor.authorFusco, Flavia
dc.contributor.authorFrogoudaki, Alexandra A.
dc.contributor.authorNir, Amiram
dc.contributor.authorChaudhry, Anisa
dc.contributor.authorJohn, Anitha S.
dc.contributor.authorKarbassi, Arsha
dc.contributor.authorHoskoppal, Arvind K.
dc.contributor.authorFrischhertz, Benjamin P.
dc.contributor.authorHendrickson, Benjamin
dc.contributor.authorBouma, Berto J.
dc.contributor.authorRodriguez-Monserrate, Carla P.
dc.contributor.authorBroda, Christopher R.
dc.contributor.authorTobler, Daniel
dc.contributor.authorGregg, David
dc.contributor.authorMartinez-Quintana, Efren
dc.contributor.authorYeung, Elizabeth
dc.contributor.authorKrieger, Eric, V
dc.contributor.authorRuperti-Repilado, Francisco J.
dc.contributor.authorGiannakoulas, George
dc.contributor.authorLui, George K.
dc.contributor.authorEphrem, Georges
dc.contributor.authorSingh, Harsimran S.
dc.contributor.authorAlmeneisi, Hassan M. K.
dc.contributor.authorBartlett, Heather L.
dc.contributor.authorLindsay, Ian
dc.contributor.authorGrewal, Jasmine
dc.contributor.authorNicolarsen, Jeremy
dc.contributor.authorAraujo, John J.
dc.contributor.authorCramer, Jonathan W.
dc.contributor.authorBouchardy, Judith
dc.contributor.authorAl Najashi, Khalid
dc.contributor.authorRyan, Kristi
dc.contributor.authorAlshawabkeh, Laith
dc.contributor.authorAndrade, Lauren
dc.contributor.authorLadouceur, Magalie
dc.contributor.authorSchwerzmann, Markus
dc.contributor.authorGreutmann, Matthias
dc.contributor.authorMeras, Pablo
dc.contributor.authorFerrero, Paolo
dc.contributor.authorDehghani, Payam
dc.contributor.authorTung, Poyee P.
dc.contributor.authorGarcia-Orta, Rocio
dc.contributor.authorTompkins, Rose O.
dc.contributor.authorGendi, Salwa M.
dc.contributor.authorCohen, Scott
dc.contributor.authorKlewer, Scott
dc.contributor.authorHascoet, Sebastien
dc.contributor.authorMohammadzadeh, Shabnam
dc.contributor.authorUpadhyay, Shailendra
dc.contributor.authorFisher, Stacy D.
dc.contributor.authorCook, Stephen
dc.contributor.authorCotts, Timothy B.
dc.contributor.authorAboulhosn, Jamil A.
dc.date.accessioned2025-01-20T23:51:22Z
dc.date.available2025-01-20T23:51:22Z
dc.date.issued2021
dc.description.abstractBACKGROUND Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications.
dc.description.abstractOBJECTIVES This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes.
dc.description.abstractMETHODS Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined.
dc.description.abstractRESULTS From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 +/- 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not.
dc.description.abstractCONCLUSIONS COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity. (C) 2021 by the American College of Cardiology Foundation.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jacc.2021.02.023
dc.identifier.eissn1558-3597
dc.identifier.issn0735-1097
dc.identifier.urihttps://doi.org/10.1016/j.jacc.2021.02.023
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94802
dc.identifier.wosidWOS:000635145700006
dc.issue.numero13
dc.language.isoen
dc.pagina.final1655
dc.pagina.inicio1644
dc.revistaJournal of the american college of cardiology
dc.rightsacceso restringido
dc.subjectadult congenital heart disease
dc.subjectcoronavirus
dc.subjectCOVID-19
dc.subjecthospitalization
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCOVID-19 in Adults With Congenital Heart Disease
dc.typeartículo
dc.volumen77
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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