Further evidence that infection is an infrequent cause of first trimester spontaneous abortion

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dc.contributor.authorSimpson, JL
dc.contributor.authorGray, RH
dc.contributor.authorQueenan, JT
dc.contributor.authorBarbato, M
dc.contributor.authorPerez, A
dc.contributor.authorMena, P
dc.contributor.authorKambic, RT
dc.contributor.authorPardo, F
dc.contributor.authorStevenson, W
dc.contributor.authorLi, CJ
dc.contributor.authorJennings, V
dc.date.accessioned2025-01-21T01:33:51Z
dc.date.available2025-01-21T01:33:51Z
dc.date.issued1996
dc.description.abstractA previous cohort study found pro clinical evidence that infection occurred more often in subjects experiencing pregnancy loss compared with those experiencing successful pregnancy [Simpson et al. (1996) Hum. Reprod, 11, 668-672]. Given these surprising findings, we conducted a similar analysis on another cohort arise followed prospectively. Using couples practising natural family planning for conception or contraception, information on clinical evidence of infection was gathered beginning with week 5 of gestation. Information on fever and signs of overt infection was specifically sought by interview and physical examination. Frequencies of urinary, vaginal and other infections in subjects experiencing pregnancy loss were 11.1, 9.5 and 8.7% respectively, not significantly different from rates in subjects having liveborns (10.1, 10.2 and 10.3% respectively). Thus, no association between clinical infection and early pregnancy loss (less than or equal to 16 weeks) was observed, Cohere studies utilizing biologically based assays are awaited because extant data do not provide evidence that clinically evident infections play major roles in first trimester pregnancy losses.
dc.description.funderNICHD NIH HHS
dc.fuente.origenWOS
dc.identifier.issn0268-1161
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97480
dc.identifier.wosidWOS:A1996VL97200052
dc.issue.numero9
dc.language.isoen
dc.pagina.final2060
dc.pagina.inicio2058
dc.revistaHuman reproduction
dc.rightsacceso restringido
dc.subjectfirst trimester
dc.subjectinfectious
dc.subjectspontaneous abortion
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleFurther evidence that infection is an infrequent cause of first trimester spontaneous abortion
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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