PHARMACOLOGICAL CHARACTERIZATION OF CGRP1-RECEPTOR SUBTYPE IN THE VASCULAR SYSTEM OF THE RAT - STUDIES WITH HCGRP FRAGMENTS AND ANALOGS

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dc.contributor.authorDONOSO, MV
dc.contributor.authorFOURNIER, A
dc.contributor.authorSTPIERRE, S
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:23:06Z
dc.date.available2025-01-23T19:23:06Z
dc.date.issued1990
dc.description.abstractIn order to examine whether the truncated fragments of hCGRP, hCGRP(8-37) or hCGRP(12-37), behave as competitive CGRP receptor antagonists in the vascular system of the rat, systemic blood pressure was continually monitored in pentobarbital-anesthetized Sprague-Dawley rats. The IV administration of 7.9-527 pmol hCGRP/rat caused dose-related reductions in mean arterial blood pressure that lasted, depending on the dose, about 3-10 min. In contrast, hCRRP fragments 8-37 or 12-37 proved inactive up to 60,000 pmol/rat. Pretreatment with either 10 or 30 nmol hCGRP(8-37) or 20 or 90 nmol hCGRP(12-37)/rat reduced the magnitude of the CGRP-induced hypotensive responses caused by 79 pmol hCRGP/rat; pretreatment with 10 nmol of the hCRGP fragments displaced about 3-fold the hCRGP as well as the [Cys(ACM)2.7]hCGRP dose-response curve to the right in a parallel fashion. The specificity of hCGRP(8-37) as a CGRP receptor antagonist was documented by the finding that it did not antagonize the hypotensive responses induced with bradykinin, histamine or substance P.
dc.fuente.origenWOS
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99162
dc.identifier.wosidWOS:A1990EA88600003
dc.issue.numero5
dc.language.isoen
dc.pagina.final889
dc.pagina.inicio885
dc.revistaPeptides
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePHARMACOLOGICAL CHARACTERIZATION OF CGRP1-RECEPTOR SUBTYPE IN THE VASCULAR SYSTEM OF THE RAT - STUDIES WITH HCGRP FRAGMENTS AND ANALOGS
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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