LARGE CATION-SELECTIVE PORES FROM RAT-LIVER PEROXISOMAL MEMBRANES INCORPORATED TO PLANAR LIPID BILAYERS

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dc.contributor.authorLABARCA, P
dc.contributor.authorWOLFF, D
dc.contributor.authorSOTO, U
dc.contributor.authorNECOCHEA, C
dc.contributor.authorLEIGHTON, F
dc.date.accessioned2025-01-23T19:26:42Z
dc.date.available2025-01-23T19:26:42Z
dc.date.issued1986
dc.description.abstractFusion of a highly purified fraction of rat liver peroxisomal membranes to planar lipid bilayers incorporates large, cation-selective voltage-dependent pores. The PK/PCl ratio of these pores estimated in KCl gradients, is close to 4. The pores display several conductance states and spend most of the time open at voltages near 0 mV, closing at more positive and negative voltages. At voltages near 0 mV the most frequent open state has a conductance of 2.4 nS in 0.3 M KCl. At voltages more positive and more negative than 10 mV the most frequent open state displays a conductance of 1.2 nS in 0.3 M KCl. With these results pore diameters of 3 and 1.5 nm, respectively, can be estimated. We suggest that these pores might account for the unusually high permeability of peroxisomes to low molecular weight solutes. Fusion also incorporates a perfectly anion-selective, two-open states channel with conductances of 50 and 100 pS in 0.1 m KCl.
dc.fuente.origenWOS
dc.identifier.eissn1432-1424
dc.identifier.issn0022-2631
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99643
dc.identifier.wosidWOS:A1986F738800010
dc.issue.numero3
dc.language.isoen
dc.pagina.final291
dc.pagina.inicio285
dc.revistaJournal of membrane biology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLARGE CATION-SELECTIVE PORES FROM RAT-LIVER PEROXISOMAL MEMBRANES INCORPORATED TO PLANAR LIPID BILAYERS
dc.typeartículo
dc.volumen94
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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