Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans

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dc.contributor.authorLi, Yingcong
dc.contributor.authorRamirez-Suastegui, Ciro
dc.contributor.authorHarris, Richard
dc.contributor.authorCastaneda-Castro, Francisco Emmanuel
dc.contributor.authorAscui, Gabriel
dc.contributor.authorPerez-Jeldres, Tamara
dc.contributor.authorDiaz, Alejandro
dc.contributor.authorMorong, Carla
dc.contributor.authorGiles, Daniel A.
dc.contributor.authorChai, Jiani
dc.contributor.authorSeumois, Gregory
dc.contributor.authorSanchez-Elsner, Tilman
dc.contributor.authorCummings, Fraser
dc.contributor.authorKronenberg, Mitchell
dc.contributor.authorVijayanand, Pandurangan
dc.date.accessioned2025-01-20T16:15:18Z
dc.date.available2025-01-20T16:15:18Z
dc.date.issued2024
dc.description.abstractTo understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from patients with UC and controls. Here we identified colonic CD4+ and CD8+ T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported in several mouse models of autoimmune disease. Stem-like T cells were increased in inflamed areas compared to non-inflamed regions from the same patients. Furthermore, TCR sequence analysis indicated stem-like T cells were clonally related to proinflammatory T cells, suggesting their involvement in sustaining effectors that drive inflammation. Using an adoptive transfer colitis model in mice, we demonstrated that CD4+ T cells deficient in either BCL-6 or TCF1, transcription factors that promote T cell stemness, had decreased colon T cells and diminished pathogenicity. Our results establish a strong association between stem-like T cell populations and UC pathogenesis, highlighting the potential of targeting this population to improve clinical outcomes.
dc.description.abstractLi et al. identify a human TCF1-expressing stem-like T cell population that is associated with immune-mediated pathogenesis in ulcerative colitis.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41590-024-01860-7
dc.identifier.eissn1529-2916
dc.identifier.issn1529-2908
dc.identifier.urihttps://doi.org/10.1038/s41590-024-01860-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90487
dc.identifier.wosidWOS:001250278500001
dc.issue.numero7
dc.language.isoen
dc.revistaNature immunology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStem-like T cells are associated with the pathogenesis of ulcerative colitis in humans
dc.typeartículo
dc.volumen25
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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