Simultaneous liver T1, T2, and ADC MR fingerprinting using optimized motion-compensated diffusion preparations: An initial validation on volunteers

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dc.article.number1572318
dc.catalogadorvdr
dc.contributor.authorVelasco, Carlos
dc.contributor.authorCastillo Passi, Carlos
dc.contributor.authorChaher, N.
dc.contributor.authorKarampinos, D.C.
dc.contributor.authorIrarrázaval Mena, Pablo
dc.contributor.authorPhinikaridou A.
dc.contributor.authorBotnar, René Michael
dc.contributor.authorPrieto Vásquez, Claudia
dc.date.accessioned2025-08-30T11:01:51Z
dc.date.available2025-08-30T11:01:51Z
dc.date.issued2025
dc.description.abstractMagnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.Purpose: To develop a novel MR fingerprinting sequence using optimized motion-compensated diffusion preparations for simultaneous T1, T2, and ADC quantification of liver tissue in a single breath-held scan. Methods: A radial spoiled gradient echo acquisition with magnetization preparation modules for T1, T2, and ADC encoding is proposed. To compensate for the signal voids generated by the diffusion preparation, the combination of (1) a breath-held scan, (2) peripheral pulse signal triggering, and (3) an optimized motion-compensated diffusion-preparation module is employed. Phantom experiments were performed to test the accuracy of the technique. The sequence was evaluated in 11 healthy subjects in comparison to conventional mapping techniques. Additional in vivo repeatability assessment experiments were performed. Results: T1, T2, and ADC quantification showed good correlation (r2 > 0.9 for all cases) with reference maps in phantoms and good agreement in vivo against clinical scans (bias not significantly different from zero). A peripheral pulse trigger delay of 200 ms was used to reduce cardiovascular motion artifacts. The repeatability tests prove a low interscan coefficient of variation and a high intraclass correlation coefficient of greater than 0.9 for all cases. Conclusions: Simultaneous quantification of T1, T2, and ADC in liver tissue in a single MR fingerprinting scan of ˜16 s has been proposed, enabling a comprehensive evaluation of hepatic disease through co-registered multiparametric imaging. Further studies are warranted to test this approach in patients with suspected diffuse liver disease to evaluate its potential for liver tissue characterization and tumor staging.
dc.description.funderANID/FONDECYT; Folios: 1250261,1250252
dc.fechaingreso.objetodigital2025-09-07
dc.format.extent16 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1002/mrm.30622
dc.identifier.eissn1550-9613
dc.identifier.issn15222594 07403194
dc.identifier.scopusidSCOPUS_ID:105010256943
dc.identifier.urihttps://doi.org/10.1002/mrm.30622
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105490
dc.identifier.wosidWOS:001510704800001
dc.information.autorucEscuela de Ingeniería; Castillo Passi, Carlos; 0000-0001-6227-0477; 204150
dc.information.autorucEscuela de Ingeniería; Irarrázaval Mena, Pablo; 0000-0002-5186-2642; 57376
dc.information.autorucEscuela de Ingeniería; Botnar, René Michael; 0000-0003-2811-2509; 1015313
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia; 0000-0003-4602-2523; 14195
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final2189
dc.pagina.inicio2173
dc.publisherCambridge University Press
dc.relation.ispartof21st Annual Conference of the International-Society-for-Environmental-Epidemiology, AUG 25-29, 2009, Dublin, IRELAND
dc.revistaMagnetic Resonance in Medicine
dc.rightsacceso abierto
dc.subjectADC
dc.subjectDiffusion imaging
dc.subjectLiver
dc.subjectMR fingerprinting
dc.subjectMRF
dc.subjectMultiparametric imaging
dc.subjectT1
dc.subjectT2
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSimultaneous liver T1, T2, and ADC MR fingerprinting using optimized motion-compensated diffusion preparations: An initial validation on volunteers
dc.typeartículo
dc.volumen94
sipa.codpersvinculados204150
sipa.codpersvinculados57376
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
sipa.indexScopus
sipa.trazabilidadWOS-SCOPUS;2025-08-30
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