Extended MRI-based PET motion correction for cardiac PET/MRI

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dc.catalogadorpau
dc.contributor.authorAizaz, Mueez
dc.contributor.authorVan der Pol, Jochem A. J.
dc.contributor.authorSchneider, Alina
dc.contributor.authorMunoz, Camila
dc.contributor.authorHoltackers, Robert J.
dc.contributor.authorVan Cauteren, Yvonne
dc.contributor.authorVan Langen, Herman
dc.contributor.authorMeeder, Joan G.
dc.contributor.authorRahel, Braim M.
dc.contributor.authorWierts, Roel
dc.contributor.authorBotnar, Rene M.
dc.contributor.authorPrieto, Claudia
dc.contributor.authorMoonen, Rik P. M.
dc.contributor.authorKooi, M. E.
dc.date.accessioned2024-04-09T21:30:51Z
dc.date.available2024-04-09T21:30:51Z
dc.date.issued2024
dc.date.updated2024-04-07T00:04:47Z
dc.description.abstractPurpose: A 2D image navigator (iNAV) based 3D whole-heart sequence has been used to perform MRI and PET non-rigid respiratory motion correction for hybrid PET/MRI. However, only the PET data acquired during the acquisition of the 3D whole-heart MRI is corrected for respiratory motion. This study introduces and evaluates an MRI-based respiratory motion correction method of the complete PET data. Methods Twelve oncology patients scheduled for an additional cardiac 18F-Fluorodeoxyglucose (18F-FDG) PET/MRI and 15 patients with coronary artery disease (CAD) scheduled for cardiac 18F-Choline (18F-FCH) PET/MRI were included. A 2D iNAV recorded the respiratory motion of the myocardium during the 3D whole-heart coronary MR angiography (CMRA) acquisition (~ 10 min). A respiratory belt was used to record the respiratory motion throughout the entire PET/MRI examination (~ 30–90 min). The simultaneously acquired iNAV and respiratory belt signal were used to divide the acquired PET data into 4 bins. The binning was then extended for the complete respiratory belt signal. Data acquired at each bin was reconstructed and combined using iNAV-based motion fields to create a respiratory motion-corrected PET image. Motion-corrected (MC) and non-motion-corrected (NMC) datasets were compared. Gating was also performed to correct cardiac motion. The SUVmax and TBRmax values were calculated for the myocardial wall or a vulnerable coronary plaque for the 18F-FDG and 18F-FCH datasets, respectively. Results A pair-wise comparison showed that the SUVmax and TBRmax values of the motion corrected (MC) datasets were significantly higher than those for the non-motion-corrected (NMC) datasets (8.2 ± 1.0 vs 7.5 ± 1.0, p < 0.01 and 1.9 ± 0.2 vs 1.2 ± 0.2, p < 0.01, respectively). In addition, the SUVmax and TBRmax of the motion corrected and gated (MC_G) reconstructions were also higher than that of the non-motion-corrected but gated (NMC_G) datasets, although for the TBRmax this difference was not statistically significant (9.6 ± 1.3 vs 9.1 ± 1.2, p = 0.02 and 2.6 ± 0.3 vs 2.4 ± 0.3, p = 0.16, respectively). The respiratory motion-correction did not lead to a change in the signal to noise ratio. Conclusion The proposed respiratory motion correction method for hybrid PET/MRI improved the image quality of cardiovascular PET scans by increased SUVmax and TBRmax values while maintaining the signal-to-noise ratio. Trial registration METC162043 registered 01/03/2017.
dc.fechaingreso.objetodigital2024-04-09
dc.format.extent18 páginas
dc.fuente.origenBiomed Central
dc.identifier.citationEJNMMI Physics. 2024 Apr 06;11(1):36
dc.identifier.doi10.1186/s40658-024-00637-z
dc.identifier.issn2197-7364
dc.identifier.urihttps://doi.org/10.1186/s40658-024-00637-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85018
dc.identifier.wosidWOS:001198026100001
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Botnar, Rene M.; 0000-0002-9447-4367; 1015313
dc.information.autorucFacultad de Matemáticas; Prieto, Claudia; 0000-0003-4602-2523; 14195
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaEJNMMI Physics
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExtended MRI-based PET motion correction for cardiac PET/MRI
dc.typeartículo
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
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