Autonomic nervous system dysfunction throughout menopausal transition: A potential mechanism underpinning cardiovascular and cognitive alterations during female ageing

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dc.catalogadorpau
dc.contributor.authorSchwarz, Karla G.
dc.contributor.authorVicencio, Sinay C.
dc.contributor.authorInestrosa, Nibaldo C.
dc.contributor.authorVillaseca P.
dc.contributor.authorDel Río, Rodrigo
dc.date.accessioned2025-11-07T19:11:59Z
dc.date.available2025-11-07T19:11:59Z
dc.date.issued2023
dc.description.abstract© 2023 The Authors. The Journal of Physiology © 2023 The Physiological Society.Cardiovascular diseases (CVD) and neurodegenerative disorders, such as Alzheimer's disease (AD), are highly prevalent conditions in middle-aged women that severely impair quality of life. Recent evidence suggests the existence of an intimate cross-talk between the heart and the brain, resulting from a complex network of neurohumoral circuits. From a pathophysiological perspective, the higher prevalence of AD in women may be explained, at least in part, by sex-related differences in the incidence/prevalence of CVD. Notably, the autonomic nervous system, the main heart–brain axis physiological orchestrator, has been suggested to play a role in the incidence of adverse cardiovascular events in middle-aged women because of decreases in oestrogen-related signalling during transition into menopause. Despite its overt relevance for public health, this hypothesis has not been thoroughly tested. Accordingly, in this review, we aim to provide up to date evidence supporting how changes in circulating oestrogen levels during transition to menopause may trigger autonomic dysfunction, thus promoting cardiovascular and cognitive decline in women. A main focus on the effects of oestrogen-mediated signalling at CNS structures related to autonomic regulation is provided, particularly on the role of oestrogens in sympathoexcitation. Improving the understanding of the contribution of the autonomic nervous system on the development, maintenance and/or progression of both cardiovascular and cognitive dysfunction during the transition to menopause should help improve the clinical management of elderly women, with the outcome being an improved life quality during the natural ageing process. (Figure presented.).
dc.fuente.origenScopus
dc.identifier.doi10.1113/JP285126
dc.identifier.eissn1469-7793
dc.identifier.issn0022-3751
dc.identifier.scopusidSCOPUS_ID:85179356998
dc.identifier.urihttps://doi.org/10.1113/JP285126
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/106688
dc.identifier.wosidWOS:001117645500001
dc.information.autorucFacultad de Ciencias Biológicas; Inestrosa Cantin, Nibaldo Manuel; 0000-0003-3118-9726; 99331
dc.information.autorucFacultad de Ciencias Biológicas; Del Rio Troncoso, Rodrigo Andre; 0000-0003-0315-6660; 126608
dc.information.autorucFacultad de Ciencias Biológicas; Schwarz Flores, Karla Gabriele; S/I; 1101566
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherJohn Wiley and Sons Inc
dc.revistaJournal of Physiology
dc.rightsacceso restringido
dc.subjectAlzheimer's disease
dc.subjectAutonomic control
dc.subjectCardiovascular disease
dc.subjectHormone therapy
dc.subjectMenopause
dc.subjectPerimenopause
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAutonomic nervous system dysfunction throughout menopausal transition: A potential mechanism underpinning cardiovascular and cognitive alterations during female ageing
dc.typeartículo
sipa.codpersvinculados99331
sipa.codpersvinculados126608
sipa.codpersvinculados1101566
sipa.trazabilidadSCOPUS;2023-12-24
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