CIPROFIBRATE, A CARCINOGENIC PEROXISOME PROLIFERATOR, INCREASES THE PHOSPHORYLATION OF EPIDERMAL-GROWTH-FACTOR RECEPTOR IN ISOLATED RAT HEPATOCYTES

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dc.contributor.authorORELLANA, A
dc.contributor.authorHOLUIGUE, L
dc.contributor.authorHIDALGO, PC
dc.contributor.authorFAUNDEZ, V
dc.contributor.authorGONZALEZ, A
dc.contributor.authorBRONFMAN, M
dc.date.accessioned2025-01-23T19:21:40Z
dc.date.available2025-01-23T19:21:40Z
dc.date.issued1993
dc.description.abstractCiprofibrate, a hypolipidaemic drug with carcinogenic and peroxisome-proliferation effects in rat liver, was found to increase the phosphorylation of epidermal-growth-factor receptor in P-32-labeled isolated rat hepatocytes. This effect was suppressed by protein-kinase-C inhibitors, and was accompanied by an almost complete inhibition of the receptor autophosphorylation normally induced by its ligand. However, in vitro experiments showed that protein-kinase-C phosphorylation of purified epidermal-growth-factor receptor was activated by ciprofibroyl-CoA, the acyl-CoA derivative of the drug, but not by the unmodified drug. Neither compound affected the ligand induction of epidermal-growth-factor-receptor autophosphorylation in isolated liver membranes. These results suggest that metabolically produced ciprofibroyl-CoA in liver cells would activate protein-kinase-C and produce changes in epidermal-growth-factor-receptor function.
dc.fuente.origenWOS
dc.identifier.issn0014-2956
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98836
dc.identifier.wosidWOS:A1993LR70200048
dc.issue.numero3
dc.language.isoen
dc.pagina.final906
dc.pagina.inicio903
dc.revistaEuropean journal of biochemistry
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCIPROFIBRATE, A CARCINOGENIC PEROXISOME PROLIFERATOR, INCREASES THE PHOSPHORYLATION OF EPIDERMAL-GROWTH-FACTOR RECEPTOR IN ISOLATED RAT HEPATOCYTES
dc.typeartículo
dc.volumen215
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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