Three-dimensional electrical impedance tomography to study regional ventilation/perfusion ratios in anesthetized pigs

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dc.contributor.authorLarrabee, Shannon
dc.contributor.authorNugen, Sarah
dc.contributor.authorBruhn, Alejandro
dc.contributor.authorPorter, Ian
dc.contributor.authorStowe, Symon
dc.contributor.authorAdler, Andy
dc.contributor.authorMartin-Flores, Manuel
dc.contributor.authorAraos, Joaquin
dc.date.accessioned2025-01-20T17:23:52Z
dc.date.available2025-01-20T17:23:52Z
dc.date.issued2023
dc.description.abstractThis study aimed to develop a three-dimensional (3-D) method for assessing ventilation/perfusion (V/Q) ratios in a pig model of hemodynamic perturbations using electrical impedance tomography (EIT). To evaluate the physiological coherence of changes in EIT-derived V/Q ratios, global EIT-derived V/Q mismatches were compared with global gold standards. The study found regional heterogeneity in the distribution of V/Q ratios in both the ventrodorsal and craniocaudal directions. Although global EIT-derived indices of V/Q mismatch consistently underestimated both low and high V/Q mismatch compared with global gold standards, the direction of the change was similar. We made the software available at no cost for other researchers to use. Future studies should compare regional V/Q ratios determined by our method against other regional, high-resolution methods.
dc.description.funderThe authors thank Drs. Stephanie Hon and Emily Pearson, from Cornell University, for assistance in the care of animals.
dc.fuente.origenWOS
dc.identifier.doi10.1152/ajplung.00180.2023
dc.identifier.eissn1522-1504
dc.identifier.issn1040-0605
dc.identifier.urihttps://doi.org/10.1152/ajplung.00180.2023
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91510
dc.identifier.wosidWOS:001100837500002
dc.issue.numero5
dc.language.isoen
dc.pagina.finalL646
dc.pagina.inicioL638
dc.revistaAmerican journal of physiology-lung cellular and molecular physiology
dc.rightsacceso restringido
dc.subjectEIT
dc.subjectlung heterogeneity
dc.subjectthree-dimensional (3-D) electrical impedance tomography
dc.subjectventilation-perfusion (V/Q) ratios
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThree-dimensional electrical impedance tomography to study regional ventilation/perfusion ratios in anesthetized pigs
dc.typeartículo
dc.volumen325
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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