Lipidomic Signature of Healthy Diet Adherence and Its Association with Cardiometabolic Risk in American Adults

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dc.article.number3995
dc.catalogadorvdr
dc.contributor.authorBerkowitz, Loni
dc.contributor.authorEcheverría, Guadalupe
dc.contributor.authorSalazar, Cristian
dc.contributor.authorFaúndez, Cristian
dc.contributor.authorCoe, Christopher L.
dc.contributor.authorRyff, Carol
dc.contributor.authorRigotti, Attilio
dc.date.accessioned2025-03-07T13:15:55Z
dc.date.available2025-03-07T13:15:55Z
dc.date.issued2024
dc.description.abstractThe aim of this study was to identify the blood lipidomic profile associated with a healthy eating pattern in a middle-aged US population sample and to determine its relationship with metabolic disorders and cardiovascular risk (CVR). Self-reported information about diet and blood samples were obtained from 2114 adult participants in the Midlife in the United States study (MIDUS). Food intake data were used to design a Healthy Diet Index (MIDUS-HEI) and to evaluate the predictive value by examining its association with health variables. The associated lipid signature (HEI-LS) was constructed using Lasso regression, from lipidomic data (LC/MS). Associations between HEI-LS, cardiometabolic biomarkers, and estimated CVR were assessed using multiple linear regression. MIDUS-HEI score was a robust indicator of dietary quality and inversely associated with body mass index (p < 0.001) and metabolic syndrome (p = 0.012). A lipidomic signature comprising 57 distinct lipid species was highly correlated with the MIDUS-HEI score (r = 0.39, p < 10⁻16). It was characterized by lower levels of saturated fatty acid and adrenic acid (n-6) and higher levels of docosahexaenoic acid (n-3). Healthier HEI-LS scores were strongly associated with better cardiometabolic indicators and lower estimated CVR (OR 0.89 CI 95% 0.87–0.91). The MIDUS-HEI effectively assessed dietary quality, confirming the link between poor diet quality and metabolic disorders in American population. Lipidomic profiling offered an objective assessment of dietary patterns and provided insights into the relationship between diet quality, metabolic responses, and CVR. This approach supports precision nutrition strategies for at-risk populations.
dc.description.funderAgencia Nacional de Investigación y Desarrollo (ANID)
dc.description.funderMacArthur Foundation
dc.description.funderUniversity of Washington
dc.description.funderNational Institute on Aging
dc.description.funderFONDECYT
dc.description.funderUniversity of California Los Angeles (UCLA)
dc.description.funderGeorgetown University
dc.fechaingreso.objetodigital2025-03-06
dc.format.extent14 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.3390/nu16233995
dc.identifier.issn2072-6643
dc.identifier.scopusidSCOPUS_ID:85211945093
dc.identifier.urihttps://doi.org/10.3390/nu16233995
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102424
dc.information.autorucEscuela de Medicina; Berkowitz, Loni; 0000-0002-8562-4845; 172010
dc.information.autorucEscuela de Medicina; Echeverría, Guadalupe; 0000-0002-2915-0171; 9504
dc.information.autorucEscuela de Medicina; Salazar, Cristian; 0009-0007-3575-2113; 1089229
dc.information.autorucEscuela de Medicina; Faúndez, Cristian; S/I; 1135593
dc.issue.numero23
dc.language.isoen
dc.pagina.final14
dc.pagina.inicio1
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.revistaNutrients
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCardiovascular risk
dc.subjectHealthy diet
dc.subjectLipid signature
dc.subjectLipidomics
dc.subjectPolyunsaturated fatty acids
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLipidomic Signature of Healthy Diet Adherence and Its Association with Cardiometabolic Risk in American Adults
dc.typeartículo
dc.volumen16
sipa.codpersvinculados172010
sipa.codpersvinculados9504
sipa.codpersvinculados1089229
sipa.codpersvinculados1135593
sipa.trazabilidadSCOPUS;2024-12-22
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