The IL-1 Family and Its Role in Atherosclerosis

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dc.article.number17
dc.catalogadoryvc
dc.contributor.authorGonzález Jara, Leticia Andrea
dc.contributor.authorRivera Vega, Katherine Solange
dc.contributor.authorAndia Kohnenkampf, Marcelo Edgardo
dc.contributor.authorMartínez Rodríguez, Gonzalo Javier
dc.date.accessioned2025-06-25T23:19:39Z
dc.date.available2025-06-25T23:19:39Z
dc.date.issued2023
dc.description.abstractThe IL-1 superfamily of cytokines is a central regulator of immunity and inflammation. The family is composed of 11 cytokines (with agonist, antagonist, and anti-inflammatory properties) and 10 receptors, all tightly regulated through decoy receptor, receptor antagonists, and signaling inhibitors. Inflammation not only is an important physiological response against infection and injury but also plays a central role in atherosclerosis development. Several clinical association studies along with experimental studies have implicated the IL-1 superfamily of cytokines and its receptors in the pathogenesis of cardiovascular disease. Here, we summarize the key features of the IL-1 family, its role in immunity and disease, and how it helps shape the development of atherosclerosis.
dc.description.funderANID/Fondecyt Regular No. 121065
dc.fechaingreso.objetodigital2025-06-25
dc.format.extent25 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.3390/ijms24010017
dc.identifier.eissn14220067
dc.identifier.issn1661-6596
dc.identifier.pubmedid36613465
dc.identifier.scopusidSCOPUS_ID: 85145979200
dc.identifier.urihttps://doi.org/10.3390/ijms24010017
dc.identifier.urihttp://www.mdpi.com/journal/ijms
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104763
dc.identifier.wosidWOS_ID: 000909393200001
dc.information.autorucEscuela de Medicina; González Jara, Leticia Andrea; S/I; 1061572
dc.information.autorucEscuela de Medicina; Rivera Vega, Katherine Solange; S/I; 1063705
dc.information.autorucEscuela de Medicina; Andia Kohnenkampf, Marcelo Edgardo; 0000-0002-1251-5832; 90691
dc.information.autorucEscuela de Medicina; Martínez Rodríguez, Gonzalo Javier; S/I; 190229
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherMDPI
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.rights.licenseCC BY Atribución Internacional 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAtherosclerosis
dc.subjectCardiovascular disease
dc.subjectInflammation
dc.subjectInterleukin-1 family
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe IL-1 Family and Its Role in Atherosclerosis
dc.typeartículo
dc.volumen24
sipa.codpersvinculados1061572
sipa.codpersvinculados1063705
sipa.codpersvinculados90691
sipa.codpersvinculados190229
sipa.trazabilidadSCOPUS;2023-03-02
sipa.trazabilidadORCID;2025-06-23
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