Altered Sensory and Stress Responses in Atopic Dermatitis: Effects of Acute Stress on Lesional and Non-Lesional Skin

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dc.article.number2
dc.contributor.authorTejos Bravo, Macarena
dc.contributor.authorCid, Dixon
dc.contributor.authorEspinoza, Fernanda
dc.contributor.authorRojas Thomas, Felipe
dc.contributor.authorTorres, Gustavo
dc.contributor.authorCossio, Maria Laura
dc.contributor.authorBorzutzky, Arturo
dc.contributor.authorCalvo, Margarita
dc.date.accessioned2025-05-01T10:32:52Z
dc.date.available2025-05-01T10:32:52Z
dc.date.issued2025
dc.description.abstractItch and pain are both mediated by small sensory fibres. Atopic dermatitis (AD) patients usually report stress-induced flares, but the impact of stress on sensory fibres in lesional and non-lesional skin remains inconclusive. This observational study assessed the effect of acute stress on sensory profiles in subjects with AD (n = 18) and healthy controls (HC, n = 21). Participants completed clinical and psychological questionnaires, and quantitative sensory testing was performed on lesional and non-lesional skin in AD and healthy skin in HC. Assessments were done before and after the Montreal Imaging Stress Task, an acute stress protocol. Stress responses were evaluated by anxiety ratings, heart rate (HR) and salivary cortisol (CORT). Cortisol binding globulin (CBG) was quantified as an indirect measure for circulating CORT. AD participants reported higher anxiety, depression and stress perception than HC. HR was similar between groups, but AD participants showed a blunted CORT response post-stress and lower CBG levels, suggesting altered stress regulation. Acute stress reduced cold sensitivity in HC and non-lesional AD skin but had no effect on lesions. These findings indicate that the effects of stress on small fibres depend on the condition of the skin and emphasise the sensory alterations experienced by AD patients.
dc.description.funderAgencia Nacional de Investigacion y Desarrollo
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/exd.70083
dc.identifier.eisbn9781665444347
dc.identifier.eissn1600-0625
dc.identifier.isbn978-1-0716-1533-1
dc.identifier.issn0906-6705
dc.identifier.pubmedid36225231
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:86000320991
dc.identifier.urihttps://doi.org/10.1111/exd.70083
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103915
dc.identifier.wosidWOS:001445783300001
dc.information.autorucEscuela de Medicina; Tejos Bravo, Macarena; S/I; 1086270
dc.information.autorucEscuela de Medicina; Cid, Dixon; S/I; 1276110
dc.information.autorucEscuela de Medicina; Rojas Thomas, Felipe; S/I; 249926
dc.information.autorucEscuela de Medicina; Cossio, Maria Laura; S/I; 16897
dc.information.autorucEscuela de Medicina; Borzutzky, Arturo; 0000-0002-7904-262X; 5897
dc.information.autorucEscuela de Medicina; Calvo, Margarita; 0000-0003-3349-9189; 3457
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final366
dc.pagina.inicio358
dc.publisherHUMANA PRESS INC
dc.relation.ispartofFrontiers in Cellular and Infection Microbiology
dc.revistaEXPERIMENTAL DERMATOLOGY
dc.rightsacceso restringido
dc.subjectAcute stress
dc.subjectAtopic dermatitis
dc.subjectLesional skin
dc.subjectNon-lesional skin
dc.subjectQuantitative sensory test
dc.subject.ddc700
dc.subject.deweyArtees_ES
dc.subject.ods11 Sustainable cities and communities
dc.subject.ods16 Peace, justice and strong institutions
dc.subject.odspa11 Ciudades y comunidades sostenibles
dc.subject.odspa16 Paz, justicia e instituciones solidas
dc.titleAltered Sensory and Stress Responses in Atopic Dermatitis: Effects of Acute Stress on Lesional and Non-Lesional Skin
dc.typeartículo
dc.volumen34
sipa.codpersvinculados1086270
sipa.codpersvinculados1276110
sipa.codpersvinculados249926
sipa.codpersvinculados16897
sipa.codpersvinculados5897
sipa.codpersvinculados3457
sipa.indexWOS
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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