THERMAL-DEPENDENCE OF CHEMOSENSORY ACTIVITY IN THE CAROTID-BODY SUPERFUSED INVITRO

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dc.contributor.authorALCAYAGA, J
dc.contributor.authorSANHUEZA, Y
dc.contributor.authorZAPATA, P
dc.date.accessioned2025-01-23T19:21:53Z
dc.date.available2025-01-23T19:21:53Z
dc.date.issued1993
dc.description.abstractWe studied the relationship between chemosensory activity and temperature in carotid bodies excised from pentobarbitone-anesthetized cats, and superfused in vitro at flows between 0.4 and 2.0 ml/min with modified Tyrode's solution buffered with HEPES at pH 7.43. The basal frequencies of chemosensory discharges were recorded from the entire carotid nerve at different steady thermal conditions. For preparations superfused with saline equilibrated with 100% O2, thermally dependent increases in frequency were observed, with significant differences between all nearby thermal stages separated by 0.5-degrees-C steps between 36.0 and 38.5-degrees-C. The larger gains were recorded between higher temperatures at high flows, between mid temperatures at intermediate flows, and between lower temperatures at low flows. The critical temperature for the calculated maximal gain was directly correlated to superfusion flow. The basal frequencies were consistently elevated when switching to saline equilibrated with 20% O2 and no significant differences in mean ranks were recorded between 36 and 37-degrees-C, as between 38 and 39-degrees-C, but frequencies at 36-37-degrees-C were significantly higher than those at 38-39-degrees-C. Brief rises in chemosensory discharges were evoked by injections of NaCN applied to carotid bodies superfused with saline equilibrated with 100% O2. The least effective dose was lower at 40-degrees-C than at 37.5-degrees or 35.0-degrees-C, but the reactivity and slope were not significantly different. It is concluded that the carotid body chemoreceptors fulfill the criteria for being considered as thermosensors, and that their frequency of discharges is thermally modulated within a range close to physiological body temperature.
dc.fuente.origenWOS
dc.identifier.issn0006-8993
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98897
dc.identifier.wosidWOS:A1993KG54000014
dc.issue.numero1
dc.language.isoen
dc.pagina.final111
dc.pagina.inicio103
dc.revistaBrain research
dc.rightsacceso restringido
dc.subjectCAROTID BODY
dc.subjectCHEMORECEPTOR
dc.subjectCHEMOSENSORY EXCITATION
dc.subjectRECEPTOR GAIN
dc.subjectTHERMAL DEPENDENCE
dc.subjectTHERMOSENSOR
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTHERMAL-DEPENDENCE OF CHEMOSENSORY ACTIVITY IN THE CAROTID-BODY SUPERFUSED INVITRO
dc.typeartículo
dc.volumen600
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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