EFFECT OF SUBCHRONIC ADMINISTRATION OF ETHANOL AND METHYLMERCURY IN COMBINATION ON THE TISSUE DISTRIBUTION OF MERCURY IN RATS

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dc.contributor.authorTURNER, CJ
dc.contributor.authorBHATNAGAR, MK
dc.contributor.authorSPEISKY, H
dc.date.accessioned2025-01-23T19:22:57Z
dc.date.available2025-01-23T19:22:57Z
dc.date.issued1990
dc.description.abstractThe effect of oral administration for 14 weeks of 8 g .cntdot. kg-1 .cntdot. day-1 ethanol and 0.5 mg .cntdot. kg-1 .cntdot. day-1 methylmercuric chloride in combination to rats fed isocaloric diets has been investigated. Ethanol, in contrast to published studies, failed to influence the tissue distribution of methylmercury and its inorganic mercury metabolite in brain and kidney, and did not inhibit the increase in kidney weight induced by methylmercury. Ethanol and methylmercury, in combination and individually, reduced the renal but not the hepatic activity of .gamma.-glutamyltransferase, but did not affect the renal and biliary concentration of reduced glutathione. Further study is required to determine the circumstances under which ethanol can influence the tissue distribution of methylmercury and its inorganic mercury metabolite.
dc.fuente.origenWOS
dc.identifier.eissn1205-7541
dc.identifier.issn0008-4212
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99135
dc.identifier.wosidWOS:A1990EL88800011
dc.issue.numero12
dc.language.isoen
dc.pagina.final1562
dc.pagina.inicio1558
dc.revistaCanadian journal of physiology and pharmacology
dc.rightsacceso restringido
dc.titleEFFECT OF SUBCHRONIC ADMINISTRATION OF ETHANOL AND METHYLMERCURY IN COMBINATION ON THE TISSUE DISTRIBUTION OF MERCURY IN RATS
dc.typeartículo
dc.volumen68
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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