The involvement of neuropeptide YY<sub>1</sub> receptors in the blood pressure baroreflex
| dc.contributor.author | Capurro, D | |
| dc.contributor.author | Huidobro-Toro, J | |
| dc.date.accessioned | 2025-01-21T01:31:58Z | |
| dc.date.available | 2025-01-21T01:31:58Z | |
| dc.date.issued | 1999 | |
| dc.description.abstract | To ascertain the role of the neuropeptide Y Y-1 receptors in the vascular manifestations of the sympathetic baroreflex, 10-s bilateral carotid occlusions were performed in anesthetized cats; systemic blood pressure was monitored continually. This maneuver rose systolic blood pressure in 23 +/- 2 mmHg. Following 100 mu g/kg BIBP 3226 or BIBO 3304 i.v., the increase in blood pressure elicited by the occlusions was only 14 +/- 1 and 15 mmHg, respectively. Both BIBP 3226 and BIBO 3304 displaced significantly 5.5 fold rightward the presser dose-response curve elicited by exogenous neuropeptide Y, without altering the norepinephrine curve. Prazosin (10 mu g/kg) reduced the presser response elicited by the carotid occlusion to 12 +/- 4 mmHg. The simultaneous administration of BIBP 3226 plus prazosin rose the systemic blood pressure following the occlusion only 9 +/- 2 mmHg, supporting the involvement of neuropeptide Y in vascular sympathetic reflexes. (C) 1999 Elsevier Science B.V. All rights reserved. | |
| dc.fuente.origen | WOS | |
| dc.identifier.issn | 0014-2999 | |
| dc.identifier.uri | https://repositorio.uc.cl/handle/11534/97179 | |
| dc.identifier.wosid | WOS:000081535700007 | |
| dc.issue.numero | 3 | |
| dc.language.iso | en | |
| dc.pagina.final | 255 | |
| dc.pagina.inicio | 251 | |
| dc.revista | European journal of pharmacology | |
| dc.rights | acceso restringido | |
| dc.subject | neuropeptide YY1 receptor | |
| dc.subject | BIBP 3226 | |
| dc.subject | BIBO 3304 | |
| dc.subject | sympathetic reflex | |
| dc.subject | sympathetic vascular control | |
| dc.subject | blood pressure homeostasis | |
| dc.subject.ods | 03 Good Health and Well-being | |
| dc.subject.ods | 02 Zero Hunger | |
| dc.subject.odspa | 03 Salud y bienestar | |
| dc.subject.odspa | 02 Hambre cero | |
| dc.title | The involvement of neuropeptide YY<sub>1</sub> receptors in the blood pressure baroreflex | |
| dc.type | artículo | |
| dc.volumen | 376 | |
| sipa.index | WOS | |
| sipa.trazabilidad | WOS;2025-01-12 |