CORRELATION BETWEEN HISTOLOGIC DATING OF HUMAN CORPUS-LUTEUM AND THE LUTEINIZING-HORMONE PEAK-BIOPSY INTERVAL
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1980
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Abstract
The accuracy of retrospective dating of ovulation in women based on the histologic dating of the corpus luteum was assessed. Corpora lutea enucleated from the ovary of 39 women from 1-6 days following the luteinizing hormone [LH] peak in plasma were examined by routine histologic techniques and dated according to Corner''s criteria. The correlation between the LH peak-biopsy interval and histologic dating was assessed. Linear regression analysis of the data gave a correlation coefficient of 0.76. The dating of different corpora lutea obtained at the same LH peak-biopsy interval can differ by as much as 4 days. The stages named by Corner as days 1 and 2 seem to develop within the first 24 h following the LH peak, while stages corresponding to days 4 and 5 each take 2 days to develop. The use of corpus luteum morphologic features for retrospective timing of ovulation is evidently subject to an error of variable magnitude due to unequal duration of each stage, and considerable individual variation.