<i>Drosophila</i> DAxud1 Has a Repressive Transcription Activity on <i>Hsp70</i> and Other Heat Shock Genes

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dc.contributor.authorZuniga-Hernandez, Jorge
dc.contributor.authorMeneses, Claudio
dc.contributor.authorBastias, Macarena
dc.contributor.authorAllende, Miguel L.
dc.contributor.authorGlavic, Alvaro
dc.date.accessioned2025-01-20T20:15:13Z
dc.date.available2025-01-20T20:15:13Z
dc.date.issued2023
dc.description.abstractDrosophila melanogaster DAxud1 is a transcription factor that belongs to the Cysteine Serine Rich Nuclear Protein (CSRNP) family, conserved in metazoans, with a transcriptional transactivation activity. According to previous studies, this protein promotes apoptosis and Wnt signaling-mediated neural crest differentiation in vertebrates. However, no analysis has been conducted to determine what other genes it might control, especially in connection with cell survival and apoptosis. To partly answer this question, this work analyzes the role of Drosophila DAxud1 using Targeted-DamID-seq (TaDa-seq), which allows whole genome screening to determine in which regions it is most frequently found. This analysis confirmed the presence of DAxud1 in groups of pro-apoptotic and Wnt pathway genes, as previously described; furthermore, stress resistance genes that coding heat shock protein (HSP) family genes were found as hsp70, hsp67, and hsp26. The enrichment of DAxud1 also identified a DNA-binding motif (AYATACATAYATA) that is frequently found in the promoters of these genes. Surprisingly, the following analyses demonstrated that DAxud1 exerts a repressive role on these genes, which are necessary for cell survival. This is coupled with the pro-apoptotic and cell cycle arrest roles of DAxud1, in which repression of hsp70 complements the maintenance of tissue homeostasis through cell survival modulation.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms24087485
dc.identifier.eissn1422-0067
dc.identifier.urihttps://doi.org/10.3390/ijms24087485
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92247
dc.identifier.wosidWOS:000977563600001
dc.issue.numero8
dc.language.isoen
dc.revistaInternational journal of molecular sciences
dc.rightsacceso restringido
dc.subjectCSRNP
dc.subjectDAxud1
dc.subjecttranscription repression
dc.subjecthsp70
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title<i>Drosophila</i> DAxud1 Has a Repressive Transcription Activity on <i>Hsp70</i> and Other Heat Shock Genes
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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