E Prostanoid-1 receptor regulates renal medullary αENaC in rats infused with angiotensin II

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dc.contributor.authorGonzalez, Alexis A.
dc.contributor.authorCespedes, Carlos
dc.contributor.authorVillanueva, Sandra
dc.contributor.authorMichea, Luis
dc.contributor.authorVio, Carlos P.
dc.date.accessioned2025-01-21T00:07:47Z
dc.date.available2025-01-21T00:07:47Z
dc.date.issued2009
dc.description.abstractE Prostanoid (EP) receptors play an important role in urinary Na+ excretion. In the kidney, the epithelial sodium channel (ENaC) is the rate-limiting-step for Na+ reabsorption. We hypothesized that activation of EP1/EP3 regulates the expression of ENaC in the face of renin-angiotensin-aldosterone-system (RAAS) activation. In primary cultures of inner medullary collecting duct (IMCD) cells, sulprostone (EP1 > EP3 agonist, 1 mu M) and 17 Phenyl trinor (17 Pt, EP1 agonist, 10 mu M) prevented the up-regulation of alpha ENaC mRNA induced by aldosterone (10 nM). In Sprague-Dawley rats infused with angiotensin II (0.4 mu g/kg/min), alpha ENaC expression was up-regulated in renal cortex and medulla coincidently with high plasma aldosterone levels. Sulprostone and/or 17 Pt prevented this effect in renal medulla but not in cortex. Immunocytochemistry demonstrated that IMCD cells express EP1. Our results suggest that specific activation of EP1 receptor during RAAS activation antagonizes the action of aldosterone on alpha ENaC expression in the renal medulla. (C) 2009 Elsevier Inc. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bbrc.2009.08.157
dc.identifier.eissn1090-2104
dc.identifier.issn0006-291X
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2009.08.157
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95643
dc.identifier.wosidWOS:000270764400031
dc.issue.numero2
dc.language.isoen
dc.pagina.final377
dc.pagina.inicio372
dc.revistaBiochemical and biophysical research communications
dc.rightsacceso restringido
dc.subjectEpithelial sodium channel (ENaC)
dc.subjectProstanoid receptor
dc.subjectProstaglandins
dc.subjectAngiotensin II
dc.subjectAldosterone
dc.subjectRenin-angiotensin-aldosterone-system
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleE Prostanoid-1 receptor regulates renal medullary αENaC in rats infused with angiotensin II
dc.typeartículo
dc.volumen389
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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