Genomics of Re-Emergent Aeromonas salmonicida in Atlantic Salmon Outbreaks

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dc.contributor.authorGodoy, Marcos
dc.contributor.authorMontes de Oca, Marco
dc.contributor.authorSuarez, Rudy
dc.contributor.authorMartinez, Alexis
dc.contributor.authorPontigo, Juan Pablo
dc.contributor.authorCaro, Diego
dc.contributor.authorKusch, Karina
dc.contributor.authorCoca, Yoandy
dc.contributor.authorBohle, Harry
dc.contributor.authorBayliss, Sion
dc.contributor.authorKibenge, Molly
dc.contributor.authorKibenge, Frederick
dc.date.accessioned2025-01-20T17:09:18Z
dc.date.available2025-01-20T17:09:18Z
dc.date.issued2024
dc.description.abstractFurunculosis, caused by Aeromonas salmonicida, poses a significant threat to both salmonid and non-salmonid fish in diverse aquatic environments. This study explores the genomic intricacies of re-emergent A. salmonicida outbreaks in Atlantic salmon (Salmo salar). Previous clinical cases have exhibited pathological characteristics, such as periorbital hemorrhages and gastrointestinal abnormalities. Genomic sequencing of three Chilean isolates (ASA04, ASA05, and CIBA_5017) and 25 previously described genomes determined the pan-genome, phylogenomics, insertion sequences, and restriction-modification systems. Unique gene families have contributed to an improved understanding of the psychrophilic and mesophilic clades, while phylogenomic analysis has been used to identify mesophilic and psychrophilic strains, thereby further differentiating between typical and atypical psychrophilic isolates. Diverse insertion sequences and restriction-modification patterns have highlighted genomic structural differences, and virulence factor predictions can emphasize exotoxin disparities, especially between psychrophilic and mesophilic strains. Thus, a novel plasmid was characterized which emphasized the role of plasmids in virulence and antibiotic resistance. The analysis of antibiotic resistance factors revealed resistance against various drug classes in Chilean strains. Overall, this study elucidates the genomic dynamics of re-emergent A. salmonicida and provides novel insights into their virulence, antibiotic resistance, and population structure.
dc.fuente.origenWOS
dc.identifier.doi10.3390/microorganisms12010064
dc.identifier.eissn2076-2607
dc.identifier.urihttps://doi.org/10.3390/microorganisms12010064
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91031
dc.identifier.wosidWOS:001153123600001
dc.issue.numero1
dc.language.isoen
dc.revistaMicroorganisms
dc.rightsacceso restringido
dc.subjectfurunculosis
dc.subjectAeromonas salmonicida
dc.subjectSalmo salar
dc.subjectgenomic diversity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGenomics of Re-Emergent Aeromonas salmonicida in Atlantic Salmon Outbreaks
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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