MATERNAL PLASMA-VOLUME EXPANSION AND HORMONAL CHANGES IN WOMEN WITH IDIOPATHIC FETAL GROWTH-RETARDATION

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dc.contributor.authorSALAS, SP
dc.contributor.authorROSSO, P
dc.contributor.authorESPINOZA, R
dc.contributor.authorROBERT, JA
dc.contributor.authorVALDES, G
dc.contributor.authorDONOSO, E
dc.date.accessioned2024-01-10T12:40:14Z
dc.date.available2024-01-10T12:40:14Z
dc.date.issued1993
dc.description.abstractObjective: To explore the mechanisms underlying the reduced maternal plasma volume associated with idiopathic fetal growth retardation (FGR).
dc.description.abstractMethods: In 30 normotensive women with growth-retarded fetuses and 26 with normal-size fetuses, plasma volume was measured with a modified Evan's blue method. Plasma levels of atrial natriuretic peptide, plasma renin activity, aldosterone, estradiol, and progesterone, and urinary excretion of kallikrein, prostacyclin, and thromboxane A2 were measured at 34-40 weeks' gestation.
dc.description.abstractResults: Compared with controls, gravidas with growth-retarded fetuses had a reduced plasma volume expansion (P < .01), similar atrial natriuretic peptide and plasma renin activity levels, and lower serum aldosterone (P < .001) and placental steroids (P < .03). These women also had decreased urinary kallikrein activity and prostaglandin excretion (P < .05). When both groups were combined, maternal plasma volume correlated significantly with birth weight (r = 0.53) and placental weight (r = 0.66).
dc.description.abstractConclusion: Normotensive women with idiopathic FGR have reduced plasma volume expansion. Although the exact mechanisms of this change are unknown, we postulate that the lower maternal aldosterone levels and reduced levels of vasodilator substances, such as prostacyclin and kallikrein, may have a causal role.
dc.fechaingreso.objetodigital2024-06-26
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.issn0029-7844
dc.identifier.pubmedidMEDLINE:8497346
dc.identifier.wosidWOS:A1993LD16900026
dc.information.autorucMedicina;Donoso E;S/I;99155
dc.information.autorucMedicina;Espinoza R;S/I;60337
dc.information.autorucMedicina;Robert J;S/I;53115
dc.information.autorucMedicina;Rosso P;S/I;98560
dc.information.autorucMedicina;Salas SP;S/I;51518
dc.information.autorucMedicina;Valdés G;S/I;98654
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1033
dc.pagina.inicio1029
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaOBSTETRICS AND GYNECOLOGY
dc.rightsacceso restringido
dc.subjectCARDIAC-OUTPUT
dc.subjectBLOOD-VOLUME
dc.subjectPREGNANCY
dc.subjectPROSTACYCLIN
dc.subjectPREECLAMPSIA
dc.subjectALDOSTERONE
dc.subjectPREVENTION
dc.subjectRENIN
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleMATERNAL PLASMA-VOLUME EXPANSION AND HORMONAL CHANGES IN WOMEN WITH IDIOPATHIC FETAL GROWTH-RETARDATION
dc.typeartículo
dc.volumen81
sipa.codpersvinculados99155
sipa.codpersvinculados60337
sipa.codpersvinculados53115
sipa.codpersvinculados98560
sipa.codpersvinculados51518
sipa.codpersvinculados98654
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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