REGIONAL SYMPATHECTOMY INDUCED BY INTRA-ARTERIAL 6-HYDROXY-DOPAMINE
No Thumbnail Available
Date
1978
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Single intra-carotid injections of 5-15 mg of 6-OHDA [6-hydroxydopamine] HBr in adult cats reduced or abolished the responses of the ipsilateral nictitating membrane to electrical stimulation of post-ganglionic sympathetic nerves and intra-carotid injections of tyramine; the responses of the contralateral nictitating membrane to the same stimuli remained normal. One to five days after 6-OHDA, the ipsilateral nictitating membranes, unresponsive to sympathetic stimulation, were hypersensitive to i.v. injections of adrenaline [epinephrine] or noradrenaline [norepinephrine]. The advantages of regional over systemic chemical sympathectomy are discussed.