High prevalence of SARS-CoV-2 detection and prolonged viral shedding in stools: A systematic review and cohort studyElevada detección de SARS-CoV-2 y prolongada excreción viral en deposiciones: Estudio de cohorte y revisión sistemática

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dc.article.number1364000
dc.contributor.authorDiaz L.A.
dc.contributor.authorChahuan J.
dc.contributor.authorAlvarez M.
dc.contributor.authorPavez C.
dc.contributor.authorCandia R.
dc.contributor.authorMonrroy H.
dc.contributor.authorEspino A.
dc.contributor.authorPizarro M.
dc.contributor.authorRiquelme A.
dc.contributor.authorGarcia-Salum T.
dc.contributor.authorLevican J.
dc.contributor.authorAlmonacid L.I.
dc.contributor.authorValenzuela G.H.
dc.contributor.authorSerrano E.
dc.contributor.authorFerres M.
dc.contributor.authorSalinas E.
dc.contributor.authorMedina R.A.
dc.contributor.authorFuentes-Lopez E.
dc.contributor.authorRiquelme A.
dc.contributor.authorReyes D.
dc.contributor.authorOrtiz J.
dc.contributor.authorRada G.
dc.contributor.authorValderrama S.
dc.contributor.authorBudnik S.
dc.contributor.authorGandara V.
dc.contributor.authorGallardo A.
dc.contributor.authorSeydewitz M.F.
dc.contributor.authorCofre C.
dc.contributor.authorRada G.
dc.contributor.authorOrtiz L.
dc.contributor.authorRada G.
dc.contributor.authorToro A.
dc.contributor.authorOrtega M.
dc.contributor.authorOrtega M.
dc.date.accessioned2024-10-15T07:00:15Z
dc.date.available2024-10-15T07:00:15Z
dc.date.issued2022
dc.description.abstract© 2022 Elsevier España, S.L.U.Objectives: To: 1. Describe the frequency of viral RNA detection in stools in a cohort of patients infected with SARS-CoV-2, and 2. Perform a systematic review to assess the clearance time in stools of SARS-CoV-2. Methods: We conducted a prospective cohort study in two centers between March and May 2020. We included SARS-CoV-2 infected patients of any age and severity. We collected seriated nasopharyngeal swabs and stool samples to detect SARS-CoV-2. After, we performed a systematic review of the prevalence and clearance of SARS-CoV-2 in stools (PROSPERO-ID: CRD42020192490). We estimated prevalence using a random-effects model. We assessed clearance time by using Kaplan–Meier curves. Results: We included 32 patients; mean age was 43.7 ± 17.7 years, 43.8% were female, and 40.6% reported gastrointestinal symptoms. Twenty-five percent (8/32) of patients had detectable viral RNA in stools. The median clearance time in stools of the cohort was 11[10–15] days. Systematic review included 30 studies (1392 patients) with stool samples. Six studies were performed in children and 55% were male. The pooled prevalence of viral detection in stools was 34.6% (twenty-four studies, 1393 patients; 95%CI:25.4–45.1); heterogeneity was high (I2:91.2%, Q:208.6; p ≤ 0.001). A meta-regression demonstrates an association between female-gender and lower presence in stools (p = 0.004). The median clearance time in stools was 22 days (nineteen studies, 140 patients; 95%CI:19–25). After 34 days, 19.9% (95%CI:11.3–29.7) of patients have a persistent detection in stools. Conclusions: Detection of SARS-CoV-2 in stools is a frequent finding. The clearance of SARS-CoV-2 in stools is prolonged and it takes longer than nasopharyngeal secretions.
dc.description.funderAgencia Nacional de Investigaci?n y Desarrollo
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.description.funderCRIP
dc.description.funderFLUOMICS Consortium
dc.description.funderNIH
dc.description.funderNIAID
dc.description.funderFONDECYT
dc.format.extent559 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.gastrohep.2021.12.009
dc.identifier.eissn15789519
dc.identifier.issn15789519 02105705
dc.identifier.pubmedid35077722
dc.identifier.scopusidSCOPUS_ID:85124898069
dc.identifier.urihttps://doi.org/10.1016/j.gastrohep.2021.12.009
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88223
dc.identifier.wosidWOS:000971085400003
dc.information.autorucFacultad de Medicina; Fuentes Lopez, Eduardo; S/I; 1013849
dc.issue.numero6
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final20
dc.pagina.inicio14
dc.relation.ispartofGastroenterologia y Hepatologia
dc.revistaGastroenterologia y Hepatologia
dc.rightsacceso abierto
dc.subject2019-nCoV-2
dc.subjectCoronavirus
dc.subjectCOVID-19
dc.subjectDiarrhea
dc.subjectNovel coronavirus
dc.subjectSARS-CoV-2
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHigh prevalence of SARS-CoV-2 detection and prolonged viral shedding in stools: A systematic review and cohort studyElevada detección de SARS-CoV-2 y prolongada excreción viral en deposiciones: Estudio de cohorte y revisión sistemática
dc.typeartículo
dc.volumen12
sipa.codpersvinculados1013849
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;15-10-2024
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